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ATVR1 serine/threonine-protein kinase receptor [ Gallus gallus (chicken) ]

Gene ID: 395246, updated on 3-Dec-2024

Summary

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Official Symbol
ATVR1provided by CGNC
Official Full Name
serine/threonine-protein kinase receptorprovided by CGNC
Primary source
CGNC:9529
See related
Ensembl:ENSGALG00010010745
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
ALK2; ACVR1
Orthologs
human mouse all
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Genomic context

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See ATVR1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
25
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (35870698..35915583, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (35790133..35835018, complement)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene cytohesin 1 interacting protein Neighboring gene activin A receptor type 1C Neighboring gene microRNA 6546 Neighboring gene uridine phosphorylase 2 Neighboring gene coiled-coil domain containing 148 Neighboring gene plakophilin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ACVR1 p.Q207E causes classic fibrodysplasia ossificans progressiva and is functionally distinct from the engineered constitutively active ACVR1 p.Q207D variant. Haupt J, et al. Hum Mol Genet, 2014 Oct 15. PMID 24852373, Free PMC Article
  2. Transforming growth factor beta (TGFbeta ) signaling via differential activation of activin receptor-like kinases 2 and 5 during cardiac development. Role in regulating parasympathetic responsiveness. Ward SM, et al. J Biol Chem, 2002 Dec 20. PMID 12393881
  3. Effects of follistatin overexpression on cell differentiation in the chick embryo retina. Moreira EF, et al. Dev Biol, 2006 Oct 1. PMID 16872597
  4. Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Desgrosellier JS, et al. Dev Biol, 2005 Apr 1. PMID 15766759
  5. ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. Zhang D, et al. J Bone Miner Res, 2003 Sep. PMID 12968668

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of ACVR1Q207D-c.a. caused severe skeletal malformations in >90% of injected embryos with large ectopic cartilage condensations in all major limb joints.
    Title: ACVR1 p.Q207E causes classic fibrodysplasia ossificans progressiva and is functionally distinct from the engineered constitutively active ACVR1 p.Q207D variant.
  2. TGFB ligands and receptors show dynamic and frequently overlapping expression patterns in numerous embryonic cell layers and structures
    Title: Embryonic expression of the transforming growth factor beta ligand and receptor genes in chicken.
  3. the expression of ROCK1 is up-regulated at the onset of endocardial epithelial-mesenchymal transition and signaling mediated by TGFbeta3/ALK2 together with BMP is involved in the expression of ROCK1
    Title: ROCK1 expression is regulated by TGFbeta3 and ALK2 during valvuloseptal endocardial cushion formation.
  4. ALK2 was expressed in isolated chick osteoblasts and chondrocytes and specifically mediated BMP signaling.
    Title: ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development.
  5. data suggest that activin receptor-like kinase (ALK) 2 activation may stimulate epithelial-mesenchymal transformation (EMT) in the atrioventricular cushion and that Smad6 may act downstream of ALK2 to negatively regulate EMT
    Title: Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation.
  6. Taken together with previous in vitro studies, our results suggest that activin is a powerful regulator of neuronal differentiation in the central nervous system.
    Title: Effects of follistatin overexpression on cell differentiation in the chick embryo retina.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables SMAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transforming growth factor beta receptor activity, type I IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dorsal/ventral pattern formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BMP receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
activin receptor type-1
Names
activin A receptor type 1
activin A receptor, type I
activin receptor type I
type I TGF B receptor
NP_001383422.1
NP_001383423.1
NP_001383424.1
NP_001383425.1
NP_001383426.1
NP_001383427.1
NP_989891.2
XP_015145612.2
XP_015145614.1
XP_015145616.1
XP_025007852.1
XP_040559188.1
XP_040559189.1
XP_040559190.1
XP_046776892.1
XP_046776893.1
XP_046776894.1
XP_046776895.1
XP_046776896.1
XP_046776897.1
XP_046776898.1
XP_046776899.1
XP_046776900.1
XP_046776901.1
XP_046776902.1
XP_046776903.1
XP_046776905.1
XP_046776906.1
XP_046776907.1
XP_046776908.1
XP_046799362.1
XP_046799363.1
XP_046799364.1
XP_046799365.1
XP_046799366.1
XP_046799367.1
XP_046799368.1
XP_046799369.1
XP_046799370.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396493.1 → NP_001383422.1  activin receptor type-1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7
    Conserved Domains (3) summary
    cd14142
    Location:197 → 494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:29 → 95
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:174 → 201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

  2. NM_001396494.1 → NP_001383423.1  activin receptor type-1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    UniProtKB/TrEMBL
    A0A8V0Y1P7
    Conserved Domains (2) summary
    smart00467
    Location:183 → 213
    GS; GS motif
    cl21453
    Location:207 → 438
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001396495.1 → NP_001383424.1  activin receptor type-1 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    Conserved Domains (2) summary
    smart00467
    Location:183 → 213
    GS; GS motif
    cl21453
    Location:207 → 346
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001396496.1 → NP_001383425.1  activin receptor type-1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7
    Related
    ENSGALP00010014502.1, ENSGALT00010025728.1
    Conserved Domains (3) summary
    cd14142
    Location:197 → 494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:29 → 95
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:174 → 201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

  5. NM_001396497.1 → NP_001383426.1  activin receptor type-1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7
    Conserved Domains (3) summary
    cd14142
    Location:197 → 494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:29 → 95
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:174 → 201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

  6. NM_001396498.1 → NP_001383427.1  activin receptor type-1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7
    Conserved Domains (3) summary
    cd14142
    Location:197 → 494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:29 → 95
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:174 → 201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

  7. NM_204560.2 → NP_989891.2  activin receptor type-1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    UniProtKB/TrEMBL
    A0A8V0Y1P7
    Related
    ENSGALP00010014519.1, ENSGALT00010025763.1
    Conserved Domains (2) summary
    smart00467
    Location:183 → 213
    GS; GS motif
    cd14142
    Location:207 → 504
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    35870698..35915583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046943411.1 → XP_046799367.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  2. XM_046943413.1 → XP_046799369.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  3. XM_015290130.3 → XP_015145616.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7
    Related
    ENSGALP00010014498.1, ENSGALT00010025721.1
    Conserved Domains (3) summary
    cd14142
    Location:197 → 494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:29 → 95
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:174 → 201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

  4. XM_046943410.1 → XP_046799366.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  5. XM_040703254.2 → XP_040559188.1  activin receptor type-1 isoform X2

    UniProtKB/TrEMBL
    A0A1D5P2D8, A0A8V0Y1P7
    Related
    ENSGALP00010014510.1, ENSGALT00010025745.1
    Conserved Domains (2) summary
    smart00467
    Location:193 → 223
    GS; GS motif
    cd14142
    Location:217 → 514
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

  6. XM_046943407.1 → XP_046799363.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  7. XM_046943414.1 → XP_046799370.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  8. XM_046943409.1 → XP_046799365.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  9. XM_015290126.4 → XP_015145612.2  activin receptor type-1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YA71
    Related
    ENSGALP00010014506.1, ENSGALT00010025736.1
    Conserved Domains (2) summary
    smart00467
    Location:257 → 287
    GS; GS motif
    cd14142
    Location:281 → 578
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

  10. XM_046943408.1 → XP_046799364.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  11. XM_046943412.1 → XP_046799368.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  12. XM_046943406.1 → XP_046799362.1  activin receptor type-1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y1R6, A0A8V0Y6D3

  13. XM_015290128.4 → XP_015145614.1  activin receptor type-1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y1R6, A0A8V0Y6D3
    Related
    ENSGALP00010014517.1, ENSGALT00010025754.1
    Conserved Domains (4) summary
    smart00220
    Location:216 → 500
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14142
    Location:209 → 506
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:37 → 108
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:186 → 213
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

  14. XM_025152084.3 → XP_025007852.1  activin receptor type-1 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Y1P7
    Conserved Domains (3) summary
    cd14142
    Location:207 → 504
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam01064
    Location:36 → 105
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:184 → 211
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

  15. XM_040703255.2 → XP_040559189.1  activin receptor type-1 isoform X5

    UniProtKB/TrEMBL
    A0A8V0Y1P7, A0A8V0YEV4
    Related
    ENSGALP00010014514.1, ENSGALT00010025751.1
    Conserved Domains (2) summary
    smart00467
    Location:182 → 212
    GS; GS motif
    cd14142
    Location:206 → 503
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

  16. XM_040703256.2 → XP_040559190.1  activin receptor type-1 isoform X6

    UniProtKB/TrEMBL
    A0A8V0Y1P7, A0A8V0YA30
    Related
    ENSGALP00010014465.1, ENSGALT00010025667.1
    Conserved Domains (2) summary
    smart00467
    Location:179 → 209
    GS; GS motif
    cd14142
    Location:203 → 500
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    35790133..35835018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046920949.1 → XP_046776905.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  2. XM_046920951.1 → XP_046776907.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  3. XM_046920945.1 → XP_046776901.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  4. XM_046920947.1 → XP_046776903.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  5. XM_046920937.1 → XP_046776893.1  activin receptor type-1 isoform X2

    UniProtKB/TrEMBL
    A0A1D5P2D8, A0A8V0Y1P7

  6. XM_046920943.1 → XP_046776899.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  7. XM_046920952.1 → XP_046776908.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  8. XM_046920946.1 → XP_046776902.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  9. XM_046920936.1 → XP_046776892.1  activin receptor type-1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YA71

  10. XM_046920944.1 → XP_046776900.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  11. XM_046920950.1 → XP_046776906.1  activin receptor type-1 isoform X7

    UniProtKB/Swiss-Prot
    Q90ZK6, Q9YH45
    UniProtKB/TrEMBL
    A0A8V0Y1P7

  12. XM_046920939.1 → XP_046776895.1  activin receptor type-1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y1R6, A0A8V0Y6D3

  13. XM_046920938.1 → XP_046776894.1  activin receptor type-1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y1R6, A0A8V0Y6D3

  14. XM_046920940.1 → XP_046776896.1  activin receptor type-1 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Y1P7

  15. XM_046920941.1 → XP_046776897.1  activin receptor type-1 isoform X5

    UniProtKB/TrEMBL
    A0A8V0Y1P7, A0A8V0YEV4

  16. XM_046920942.1 → XP_046776898.1  activin receptor type-1 isoform X6

    UniProtKB/TrEMBL
    A0A8V0Y1P7, A0A8V0YA30
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90ZK6.1 GenPept UniProtKB/Swiss-Prot:Q90ZK6

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