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ATM ATM serine/threonine kinase [ Gallus gallus (chicken) ]

Gene ID: 395401, updated on 3-Dec-2024

Summary

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Symbol
ATMprovided by CGNC
Full Name
ATM serine/threonine kinaseprovided by CGNC
Primary source
CGNC:12888
See related
Ensembl:ENSGALG00010004824
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See ATM in Genome Data Viewer
Location:
chromosome: 1
Exon count:
64
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (180132376..180192071, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (180164989..180224719, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121113484 Neighboring gene KDEL motif containing 2 Neighboring gene uncharacterized LOC121109181 Neighboring gene nuclear protein, coactivator of histone transcription Neighboring gene acetyl-CoA acetyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation. Takao N, et al. Oncogene, 1999 Nov 25. PMID 10597300
  2. ATM-mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells. Ren S, et al. PLoS Pathog, 2020 Jun. PMID 32479542, Free PMC Article
  3. DNA damage precedes apoptosis during the regression of the interdigital tissue in vertebrate embryos. Montero JA, et al. Sci Rep, 2016 Oct 18. PMID 27752097, Free PMC Article
  4. Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags. Hubbard SJ, et al. Genome Res, 2005 Jan. PMID 15590942, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATM-mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells.
    Title: ATM-mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells.
  2. Phosphorylation of H2AX mediated by ATM precedes caspase dependent apoptosis and cell senescence during interdigit regression.
    Title: DNA damage precedes apoptosis during the regression of the interdigital tissue in vertebrate embryos.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine-protein kinase ATM
Names
ATM (ataxia telangiectasia mutated)
ataxia telangiectasia mutated (includes complementation groups A, C and D)
NP_001155872.2
XP_015133057.2
XP_015133060.2
XP_025010375.2
XP_025010397.2
XP_025010458.2
XP_040502432.1
XP_040502482.1
XP_040502525.1
XP_046762513.1
XP_046762514.1
XP_046762515.1
XP_046762516.1
XP_046762517.1
XP_046762518.1
XP_046762519.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162400.2 → NP_001155872.2  serine-protein kinase ATM

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000027
    UniProtKB/TrEMBL
    A0A8V0XNG7

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    180132376..180192071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040646498.2 → XP_040502432.1  serine-protein kinase ATM isoform X3

    UniProtKB/TrEMBL
    A0A8V0XNG7
    Conserved Domains (2) summary
    COG5032
    Location:1887 → 3017
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05171
    Location:2645 → 2924
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated

  2. XM_015277574.4 → XP_015133060.2  serine-protein kinase ATM isoform X2

    UniProtKB/TrEMBL
    A0A8V0XNG7
    Related
    ENSGALP00010006360.1, ENSGALT00010011290.1
    Conserved Domains (2) summary
    COG5032
    Location:2008 → 3068
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05171
    Location:2697 → 2976
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated

  3. XM_015277571.4 → XP_015133057.2  serine-protein kinase ATM isoform X1

    UniProtKB/TrEMBL
    A0A8V0XI18, A0A8V0XNG7
    Related
    ENSGALP00010006351.1, ENSGALT00010011261.1
    Conserved Domains (2) summary
    COG5032
    Location:2008 → 3069
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05171
    Location:2697 → 2976
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated

  4. XM_040646548.2 → XP_040502482.1  serine-protein kinase ATM isoform X4

    UniProtKB/TrEMBL
    A0A8V0XNG7
    Conserved Domains (2) summary
    COG5032
    Location:1586 → 2647
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05171
    Location:2275 → 2554
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated

  5. XM_040646591.2 → XP_040502525.1  serine-protein kinase ATM isoform X5

  6. XM_025154607.3 → XP_025010375.2  serine-protein kinase ATM isoform X6

  7. XM_025154629.3 → XP_025010397.2  serine-protein kinase ATM isoform X7

  8. XM_025154690.3 → XP_025010458.2  serine-protein kinase ATM isoform X8

RNA

  1. XR_003077418.3 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    180164989..180224719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906559.1 → XP_046762515.1  serine-protein kinase ATM isoform X3

    UniProtKB/TrEMBL
    A0A8V0XNG7

  2. XM_046906558.1 → XP_046762514.1  serine-protein kinase ATM isoform X2

    UniProtKB/TrEMBL
    A0A8V0XNG7

  3. XM_046906557.1 → XP_046762513.1  serine-protein kinase ATM isoform X1

    UniProtKB/TrEMBL
    A0A8V0XNG7

  4. XM_046906560.1 → XP_046762516.1  serine-protein kinase ATM isoform X5

  5. XM_046906561.1 → XP_046762517.1  serine-protein kinase ATM isoform X6

  6. XM_046906562.1 → XP_046762518.1  serine-protein kinase ATM isoform X7

  7. XM_046906563.1 → XP_046762519.1  serine-protein kinase ATM isoform X8

RNA

  1. XR_006932632.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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