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Ptip PAX transcription activation domain interacting protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39552, updated on 9-Dec-2024

Summary

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Official Symbol
Ptipprovided by FlyBase
Official Full Name
PAX transcription activation domain interacting proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0052133
Locus tag
Dmel_CG32133
See related
AllianceGenome:FB:FBgn0052133
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32133; CG6532; CG8797; Dmel\CG32133; ptip; PTIP
Summary
Involved in anterior/posterior pattern specification, imaginal disc; embryonic pattern specification; and positive regulation of antibacterial peptide biosynthetic process. Part of MLL3/4 complex. Is expressed in several structures, including gland; gut section; imaginal disc; larval central nervous system; and larval ventral nerve cord. Orthologous to human PAXIP1 (PAX interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ptip in Genome Data Viewer
Location:
70C12-70C14; 3-41 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14020315..14029121, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14013415..14022221, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Nitrogen permease regulator-like 3 Neighboring gene upSET Neighboring gene endosulfine Neighboring gene antisense RNA:CR42871 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance. Dong YL, et al. Commun Biol, 2021 Mar 19. PMID 33742110, Free PMC Article
  2. Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Herz HM, et al. Genes Dev, 2012 Dec 1. PMID 23166019, Free PMC Article
  3. Genome-wide analysis of bivalent histone modifications during Drosophila embryogenesis. Cheng Q, et al. Genesis, 2022 Dec. PMID 36125264
  4. An essential role for PTIP in mediating Hox gene regulation along PcG and trxG pathways. Cheng Q, et al. FEBS J, 2022 Oct. PMID 35655387
  5. The COMPASS family of H3K4 methylases in Drosophila. Mohan M, et al. Mol Cell Biol, 2011 Nov. PMID 21875999, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in anterior/posterior pattern specification, imaginal disc IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of antibacterial peptide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MLL3/4 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MLL3/4 complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
PAX transcription activation domain interacting protein
Names
CG32133-PA
PAX transcription activation domain-interacting protein
Ptip-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14020315..14029121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168571.3 → NP_729947.2  PAX transcription activation domain interacting protein [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729947.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUB7
    Related
    FBpp0075526
    Conserved Domains (4) summary
    smart00292
    Location:9 → 77
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:1814 → 1887
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam00533
    Location:96 → 174
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12738
    Location:1914 → 1976
    PTCB-BRCT; twin BRCT domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VUB7 Q9VUB7

Gene LinkOut

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