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CG6833 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39559, updated on 4-Jan-2025

Summary

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Official Symbol
CG6833provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036405
Locus tag
Dmel_CG6833
See related
AllianceGenome:FB:FBgn0036405
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6833; REXO4
Summary
Predicted to enable exonuclease activity. Predicted to be involved in DNA catabolic process and RNA processing. Predicted to be active in nucleus. Is expressed in organism and spermatozoon. Orthologous to human REXO4 (REX4 homolog, 3'-5' exonuclease). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG6833 in Genome Data Viewer
Location:
70D1-70D1; 3-42 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14051206..14052469)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14044306..14045569)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Heat shock protein 110 Neighboring gene Neuralized E3 ubiquitin protein ligase 4 Neighboring gene antisense RNA:CR46067 Neighboring gene uncharacterized protein Neighboring gene Formin-like Neighboring gene Peroxin 1 Neighboring gene breathless

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neurl4 contributes to germ cell formation and integrity in Drosophila. Jones J, et al. Biol Open, 2015 Jun 26. PMID 26116656, Free PMC Article
  2. Unique and Overlapping Functions of Formins Frl and DAAM During Ommatidial Rotation and Neuronal Development in Drosophila. Dollar G, et al. Genetics, 2016 Mar. PMID 26801180, Free PMC Article
  3. The Conserved RNA Exonuclease Rexo5 Is Required for 3' End Maturation of 28S rRNA, 5S rRNA, and snoRNAs. Gerstberger S, et al. Cell Rep, 2017 Oct 17. PMID 29045842, Free PMC Article
  4. Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila. Rech GE, et al. Nat Commun, 2022 Apr 12. PMID 35413957, Free PMC Article
  5. The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1. Han BW, et al. Curr Biol, 2011 Nov 22. PMID 22055293, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3'-5' exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6833-PA
CG6833-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14051206..14052469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140432.5 → NP_648689.1  uncharacterized protein Dmel_CG6833, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648689.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUC3
    Related
    FBpp0075516
    Conserved Domains (2) summary
    cd06144
    Location:118 → 270
    REX4_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product of 20 kDa, and similar proteins
    COG0847
    Location:100 → 283
    DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]

  2. NM_001202176.2 → NP_001189105.1  uncharacterized protein Dmel_CG6833, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189105.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUC3
    Conserved Domains (2) summary
    cd06144
    Location:118 → 270
    REX4_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product of 20 kDa, and similar proteins
    COG0847
    Location:100 → 283
    DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VUC3 Q9VUC3

Gene LinkOut

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