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RGS12 regulator of G-protein signaling 12 [ Gallus gallus (chicken) ]

Gene ID: 395619, updated on 17-Aug-2024

Summary

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Symbol
RGS12provided by CGNC
Full Name
regulator of G-protein signaling 12provided by CGNC
Primary source
CGNC:11649
See related
Ensembl:ENSGALG00010016340
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See RGS12 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
22
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (81489915..81575255, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (81467886..81553296, complement)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene docking protein 7 Neighboring gene coagulation factor XII Neighboring gene Myb/SANT DNA binding domain containing 1 Neighboring gene huntingtin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RGS12 interacts with the SNARE-binding region of the Cav2.2 calcium channel. Richman RW, et al. J Biol Chem, 2005 Jan 14. PMID 15536086
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
regulator of G-protein signaling 12
Names
regulator of G-protein signalling 12

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    81489915..81575255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040699315.2 → XP_040555249.1  regulator of G-protein signaling 12 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YVQ2
    Conserved Domains (6) summary
    cd08742
    Location:709 → 823
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:1182 → 1203
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:226 → 357
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:957 → 1026
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:1027 → 1099
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  2. XM_040699314.2 → XP_040555248.1  regulator of G-protein signaling 12 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YVQ2, A0A8V0Z254
    Related
    ENSGALP00010022701.1, ENSGALT00010039345.1
    Conserved Domains (6) summary
    cd08742
    Location:709 → 823
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:1182 → 1203
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:226 → 357
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:957 → 1026
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:1027 → 1099
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  3. XM_420820.8 → XP_420820.5  regulator of G-protein signaling 12 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YVQ2
    Related
    ENSGALP00010022704.1, ENSGALT00010039348.1
    Conserved Domains (6) summary
    cd08742
    Location:709 → 823
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:1182 → 1203
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:226 → 357
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:957 → 1026
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:1027 → 1099
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  4. XM_046940662.1 → XP_046796618.1  regulator of G-protein signaling 12 isoform X10

  5. XM_040699317.2 → XP_040555251.1  regulator of G-protein signaling 12 isoform X6

    Conserved Domains (4) summary
    cd08742
    Location:61 → 175
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:534 → 555
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17136
    Location:309 → 378
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:379 → 451
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  6. XM_046940661.1 → XP_046796617.1  regulator of G-protein signaling 12 isoform X10

  7. XM_040699316.2 → XP_040555250.1  regulator of G-protein signaling 12 isoform X5

    Conserved Domains (4) summary
    cd08742
    Location:69 → 183
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:542 → 563
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17136
    Location:317 → 386
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:387 → 459
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  8. XM_015285851.4 → XP_015141337.2  regulator of G-protein signaling 12 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YNW2
    Related
    ENSGALP00010022695.1, ENSGALT00010039339.1
    Conserved Domains (5) summary
    cd08742
    Location:709 → 823
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:226 → 357
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:957 → 1026
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:1027 → 1099
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  9. XM_046940660.1 → XP_046796616.1  regulator of G-protein signaling 12 isoform X9

    UniProtKB/TrEMBL
    A0A8V0YVN7
    Related
    ENSGALP00010022689.1, ENSGALT00010039332.1

  10. XM_040699318.2 → XP_040555252.1  regulator of G-protein signaling 12 isoform X8

    UniProtKB/TrEMBL
    A0A8V0Z233
    Related
    ENSGALP00010022680.1, ENSGALT00010039321.1
    Conserved Domains (4) summary
    cd08742
    Location:61 → 175
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:534 → 555
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17136
    Location:309 → 378
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:379 → 451
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  11. XM_046940659.1 → XP_046796615.1  regulator of G-protein signaling 12 isoform X7

    UniProtKB/TrEMBL
    A0A8V0YNT8
    Related
    ENSGALP00010022674.1, ENSGALT00010039312.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    81467886..81553296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040670137.2 → XP_040526071.1  regulator of G-protein signaling 12 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YVQ2
    Conserved Domains (6) summary
    cd08742
    Location:709 → 823
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:1182 → 1203
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:226 → 357
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:957 → 1026
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:1027 → 1099
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  2. XM_040670135.2 → XP_040526069.1  regulator of G-protein signaling 12 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YVQ2
    Conserved Domains (6) summary
    cd08742
    Location:709 → 823
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:1182 → 1203
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:226 → 357
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:957 → 1026
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:1027 → 1099
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  3. XM_040670136.2 → XP_040526070.1  regulator of G-protein signaling 12 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YVQ2
    Conserved Domains (6) summary
    cd08742
    Location:709 → 823
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:1182 → 1203
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:226 → 357
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:957 → 1026
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:1027 → 1099
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  4. XM_046916924.1 → XP_046772880.1  regulator of G-protein signaling 12 isoform X10

  5. XM_040670140.2 → XP_040526074.1  regulator of G-protein signaling 12 isoform X6

    Conserved Domains (4) summary
    cd08742
    Location:61 → 175
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:534 → 555
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17136
    Location:309 → 378
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:379 → 451
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  6. XM_046916923.1 → XP_046772879.1  regulator of G-protein signaling 12 isoform X10

  7. XM_040670139.2 → XP_040526073.1  regulator of G-protein signaling 12 isoform X5

    Conserved Domains (4) summary
    cd08742
    Location:69 → 183
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:542 → 563
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17136
    Location:317 → 386
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:387 → 459
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  8. XM_040670138.2 → XP_040526072.1  regulator of G-protein signaling 12 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YNW2
    Conserved Domains (5) summary
    cd08742
    Location:709 → 823
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:226 → 357
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:957 → 1026
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:1027 → 1099
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  9. XM_046916922.1 → XP_046772878.1  regulator of G-protein signaling 12 isoform X9

  10. XM_040670141.2 → XP_040526075.1  regulator of G-protein signaling 12 isoform X8

    Conserved Domains (4) summary
    cd08742
    Location:61 → 175
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:534 → 555
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17136
    Location:309 → 378
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:379 → 451
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  11. XM_046916921.1 → XP_046772877.1  regulator of G-protein signaling 12 isoform X7

Nucleotide Protein
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