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SMAD5 SMAD family member 5 [ Gallus gallus (chicken) ]

Gene ID: 395679, updated on 3-Dec-2024

Summary

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Official Symbol
SMAD5provided by CGNC
Official Full Name
SMAD family member 5provided by CGNC
Primary source
CGNC:4741
See related
Ensembl:ENSGALG00010015829
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
MADH5
Orthologs
human mouse all
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Genomic context

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See SMAD5 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
9
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 13 NC_052544.1 (14708163..14734083, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 13 NC_052585.1 (14720374..14746289, complement)

Chromosome 13 - NC_052544.1Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel subfamily C member 7 Neighboring gene uncharacterized LOC101749758 Neighboring gene uncharacterized LOC101749540 Neighboring gene uncharacterized LOC121106742 Neighboring gene transforming growth factor beta induced

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Retinoic acid promotes expression of germline-specific genes in chicken blastoderm cells by stimulating Smad1/5 phosphorylation in a feeder-free culture system. Tang X, et al. BMC Biotechnol, 2017 Feb 20. PMID 28219352, Free PMC Article
  2. Early avian follicular development is characterized by changes in transcripts involved in steroidogenesis, paracrine signaling and transcription. Diaz FJ, et al. Mol Reprod Dev, 2011 Mar. PMID 21308853
  3. Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity. Suzuki T, et al. Proc Natl Acad Sci U S A, 2008 Mar 18. PMID 18334652, Free PMC Article
  4. Activin potentiates proliferation in mature avian auditory sensory epithelium. McCullar JS, et al. J Neurosci, 2010 Jan 13. PMID 20071511, Free PMC Article
  5. Bmp2 antagonizes sonic hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling. Rios I, et al. Development, 2004 Jul. PMID 15197161

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our results demonstrated that E8 medium is able to maintain cBC growth for weeks and RA treatment induced germ cell differentiation of cBCs through the BMP-Smad1/5 signaling pathway.
    Title: Retinoic acid promotes expression of germline-specific genes in chicken blastoderm cells by stimulating Smad1/5 phosphorylation in a feeder-free culture system.
  2. each digital phalanx-forming region has a unique p-SMAD1/5/8 activity signature
    Title: Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity.
  3. Bmp2-mediated Smad5 signalling suppresses the proliferative response to Shh by downregulation of the pathway, and allows granule cell precursor to enter their differentiation programme
    Title: Bmp2 antagonizes sonic hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables I-SMAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of heteromeric SMAD protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mothers against decapentaplegic homolog 5
Names
MAD homolog 5
SMAD 5
SMAD, mothers against DPP homolog 5
mothers against DPP homolog 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014968.1 → NP_001014968.1  mothers against decapentaplegic homolog 5

    See identical proteins and their annotated locations for NP_001014968.1

    Status: PROVISIONAL

    Source sequence(s)
    AY953144
    UniProtKB/Swiss-Prot
    Q56I99
    UniProtKB/TrEMBL
    A0A8V0YV96
    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    14708163..14734083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046900290.1 → XP_046756246.1  mothers against decapentaplegic homolog 5 isoform X1

    UniProtKB/Swiss-Prot
    Q56I99
    UniProtKB/TrEMBL
    A0A8V0YV96
    Related
    ENSGALP00010021994.1, ENSGALT00010038121.1

  2. XM_015293967.4 → XP_015149453.1  mothers against decapentaplegic homolog 5 isoform X1

    UniProtKB/Swiss-Prot
    Q56I99
    UniProtKB/TrEMBL
    A0A8V0YV96
    Related
    ENSGALP00010021999.1, ENSGALT00010038128.1
    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

  3. XM_046900287.1 → XP_046756243.1  mothers against decapentaplegic homolog 5 isoform X1

    UniProtKB/Swiss-Prot
    Q56I99
    UniProtKB/TrEMBL
    A0A8V0YV96

  4. XM_046900289.1 → XP_046756245.1  mothers against decapentaplegic homolog 5 isoform X1

    UniProtKB/Swiss-Prot
    Q56I99
    UniProtKB/TrEMBL
    A0A8V0YV96

  5. XM_046900288.1 → XP_046756244.1  mothers against decapentaplegic homolog 5 isoform X1

    UniProtKB/Swiss-Prot
    Q56I99
    UniProtKB/TrEMBL
    A0A8V0YV96

  6. XM_040646853.2 → XP_040502787.1  mothers against decapentaplegic homolog 5 isoform X1

    UniProtKB/Swiss-Prot
    Q56I99
    UniProtKB/TrEMBL
    A0A8V0YV96
    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    14720374..14746289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046926836.1 → XP_046782792.1  mothers against decapentaplegic homolog 5 isoform X1

    UniProtKB/Swiss-Prot
    Q56I99
    UniProtKB/TrEMBL
    A0A8V0YV96

  2. XM_046926832.1 → XP_046782788.1  mothers against decapentaplegic homolog 5 isoform X1

    UniProtKB/Swiss-Prot
    Q56I99
    UniProtKB/TrEMBL
    A0A8V0YV96

  3. XM_046926833.1 → XP_046782789.1  mothers against decapentaplegic homolog 5 isoform X1

    UniProtKB/Swiss-Prot
    Q56I99
    UniProtKB/TrEMBL
    A0A8V0YV96

  4. XM_046926835.1 → XP_046782791.1  mothers against decapentaplegic homolog 5 isoform X1

    UniProtKB/Swiss-Prot
    Q56I99
    UniProtKB/TrEMBL
    A0A8V0YV96

  5. XM_046926834.1 → XP_046782790.1  mothers against decapentaplegic homolog 5 isoform X1

    UniProtKB/Swiss-Prot
    Q56I99
    UniProtKB/TrEMBL
    A0A8V0YV96
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q56I99.1 GenPept UniProtKB/Swiss-Prot:Q56I99

Gene LinkOut

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