AvBD1 avian beta-defensin 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: AvBD1provided by CGNC
Full Name: avian beta-defensin 1provided by CGNC
Primary source: CGNC:49508
See related: Ensembl:ENSGALG00010007863
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: GAL1; GAL 1
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Genomic context

Location:: chromosome: 3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	3	NC_052534.1 (107258159..107260603, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	3	NC_052575.1 (107020864..107023308, complement)

Chromosome 3 - NC_052534.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tissue-, age- and dose-dependent changes in avian beta-defensin and LEAP2 mRNA abundance in the intestines of Salmonella Typhimurium challenged broilers.
Title: Tissue-, age- and dose-dependent changes in avian β-defensin and LEAP2 mRNA abundance in the intestines of Salmonella Typhimurium challenged broilers.
Authors use expression of beta-defensins GAL1 and GLA2 to postulate in situ maturation of heterophils in hatchling gut tissue.
Title: Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick.
The chicken genome encodes only beta-defensins. The 13 chicken beta-defensin genes are clustered densely within a 86-Kb distance on the chromosome 3q3.5-q3.7. The deduced peptides share the characteristic defensin motif.
Title: A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins.
mRNA expression of Gal-1, -2 and -3 in the vagina of laying hens increases with age but decreases in the regressed oviduct during the non-laying phase, and may increase in response to Salmonella enteritidis (SE) and lipopolysaccharide
Title: Effects of age, egg-laying activity, and Salmonella-inoculation on the expressions of gallinacin mRNA in the vagina of the hen oviduct.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables CCR6 chemokine receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables chemoattractant activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: gallinacin-1 alpha

Names: Gal 1-alpha; antimicrobial peptide 1; antimicrobial peptide CHP2; beta-defensin 1 antimicrobial peptide; chicken heterophil peptide 2; gal-1 alpha; gallinacin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204993.1 → NP_990324.1 gallinacin-1 alpha precursor

See identical proteins and their annotated locations for NP_990324.1

Status: PROVISIONAL

Source sequence(s)

AF033335

UniProtKB/Swiss-Prot

P46156, P46157, P80390, Q09MK1, Q09MR8, Q0PWH4, Q6B9W7, Q6GXJ4, Q9DG59

UniProtKB/TrEMBL

E5KV52, E5KV53

Related

ENSGALP00010010266.1, ENSGALT00010018716.1

Conserved Domains (1) summary

pfam00711
Location:31 → 61

Defensin_beta; Beta defensin

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

107258159..107260603 complement

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Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

107020864..107023308 complement

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GenBank, FASTA, Sequence Viewer (Graphics)