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PITX2 paired like homeodomain 2 [ Gallus gallus (chicken) ]

Gene ID: 395862, updated on 17-Aug-2024

Summary

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Symbol
PITX2provided by CGNC
Full Name
paired like homeodomain 2provided by CGNC
Primary source
CGNC:66216
See related
Ensembl:ENSGALG00010003740
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
Ptx2
Orthologs
human mouse all
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Genomic context

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See PITX2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
6
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (57302703..57316791)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (57306548..57320910)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene chromosome 4 open reading frame, human C4orf32 Neighboring gene adaptor related protein complex 1 associated regulatory protein Neighboring gene translation initiation factor IF-2-like Neighboring gene collagen alpha-1(I) chain-like Neighboring gene uncharacterized LOC121110595 Neighboring gene glutamyl aminopeptidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The transcription factor Pitx2 positions the embryonic axis and regulates twinning. Torlopp A, et al. Elife, 2014 Dec 11. PMID 25496870, Free PMC Article
  2. The Pitx2c N-terminal domain is a critical interaction domain required for asymmetric morphogenesis. Simard A, et al. Dev Dyn, 2009 Oct. PMID 19681163, Free PMC Article
  3. PITX2 controls asymmetric gonadal development in both sexes of the chick and can rescue the degeneration of the right ovary. Guioli S, et al. Development, 2007 Dec. PMID 17959721
  4. Cloning and expression pattern of chicken Pitx2: a new component in the SHH signaling pathway controlling embryonic heart looping. St Amand TR, et al. Biochem Biophys Res Commun, 1998 Jun 9. PMID 9636662
  5. Altered PITX2 and LEF1 gene expression in the cadmium-induced omphalocele in the chick model. Doi T, et al. Pediatr Surg Int, 2011 May. PMID 21259014

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pitx2 is essential for axis formation, and that it acts as a direct regulator of cVg1 expression by binding to enhancers within neighbouring genes.
    Title: The transcription factor Pitx2 positions the embryonic axis and regulates twinning.
  2. Pitx2 pathway drives organ-specific arterial and lymphatic development in the intestine
    Title: The left-right Pitx2 pathway drives organ-specific arterial and lymphatic development in the intestine.
  3. Downregulation of PITX2 and LEF1 genes may interfere with ventral body wall formation in Cd chick model causing omphalocele by disrupting somite myogenesis.
    Title: Altered PITX2 and LEF1 gene expression in the cadmium-induced omphalocele in the chick model.
  4. Wnt/Lef1 signaling regulates epaxial myogenesis via Pitx2.
    Title: Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis.
  5. Data suggest that the Pitx2c N-terminal domain competes with endogenous Pitx2c for binding to a protein interaction partner that is required for the activation of genes that direct asymmetric morphogenesis along the left-right axis.
    Title: The Pitx2c N-terminal domain is a critical interaction domain required for asymmetric morphogenesis.
  6. Pitx2 is together with Pax6 expressed in the entire domain of the Rathke's pouch.
    Title: Expression patterns of Shh, Ptc2, Raldh3, Pitx2, Isl1, Lim3 and Pax6 in the developing chick hypophyseal placode and Rathke's pouch.
  7. Pitx2 activity directs asymmetrical gonad morphogenesis by controlling mitotic spindle orientation of the developing gonad cortex and how, by modulating cyclinD1 expression during asymmetric ovarian development
    Title: Pitx2 regulates gonad morphogenesis.
  8. Mechanism in females that actively promotes the underlying L-R asymmetry initiated by Pitx2 and the degeneration of the right gonad, and a mechanism in males that allows it to be ignored or overridden.
    Title: PITX2 controls asymmetric gonadal development in both sexes of the chick and can rescue the degeneration of the right ovary.
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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pituitary homeobox 2
Names
cPITX2
homeobox protein PITX2
paired-like homeodomain transcription factor 2
transcription factor Pitx2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205010.2 → NP_990341.2  pituitary homeobox 2

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000074
    UniProtKB/Swiss-Prot
    O73854, O93385, Q9PWE0
    UniProtKB/TrEMBL
    A0A1D5P1S6
    Related
    ENSGALP00010005058.1, ENSGALT00010008638.1
    Conserved Domains (2) summary
    pfam00046
    Location:105 → 158
    Homeobox; Homeobox domain
    pfam03826
    Location:291 → 308
    OAR; OAR domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    57302703..57316791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025149516.3 → XP_025005284.1  pituitary homeobox 2 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P150
    Related
    ENSGALP00010005059.1, ENSGALT00010008640.1
    Conserved Domains (2) summary
    pfam00046
    Location:43 → 96
    Homeobox; Homeobox domain
    pfam03826
    Location:229 → 246
    OAR; OAR domain

  2. XM_025149515.3 → XP_025005283.1  pituitary homeobox 2 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P150
    Conserved Domains (2) summary
    pfam00046
    Location:43 → 96
    Homeobox; Homeobox domain
    pfam03826
    Location:229 → 246
    OAR; OAR domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    57306548..57320910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046915530.1 → XP_046771486.1  pituitary homeobox 2 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P150

  2. XM_046915529.1 → XP_046771485.1  pituitary homeobox 2 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P150
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O93385.1 GenPept UniProtKB/Swiss-Prot:O93385

Gene LinkOut

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Molecular Biology Databases
Research Materials