DIO3 deiodinase, iodothyronine type III [Gallus gallus (chicken)] - Gene

Summary

Symbol: DIO3provided by CGNC
Full Name: deiodinase, iodothyronine type IIIprovided by CGNC
Primary source: CGNC:66218
See related: Ensembl:ENSGALG00010018081
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Summary: The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. As in mammals, studies in chicken show that this enzyme is involved in embryonic development. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jun 2016]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	5	NC_052536.1 (48804584..48806066)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	5	NC_052577.1 (48781143..48782644)

Chromosome 5 - NC_052536.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

D3 are expressed in the choroid plexus and several sensory brain centers
Title: Dynamic mRNA distribution pattern of thyroid hormone transporters and deiodinases during early embryonic chicken brain development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables thyroxine 5'-deiodinase activity	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: thyroxine 5-deiodinase

Names: 5DIII; DIOIII; iodothyronine deiodinase 3; type 3 DI; type III iodothyronine deiodinase; type-III 5'-deiodinase

NP_001116120.1

EC 1.21.99.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122648.3 → NP_001116120.1 thyroxine 5-deiodinase

Status: REVIEWED

Source sequence(s)

JAENSK010000215

UniProtKB/TrEMBL

A0A8V0ZBZ3

Related

ENSGALP00010026012.1, ENSGALT00010043718.1

Conserved Domains (1) summary

cl00388
Location:12 → 260

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold