U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LRP8 LDL receptor related protein 8 [ Gallus gallus (chicken) ]

Gene ID: 396102, updated on 3-Dec-2024

Summary

Go to the top of the page Help
Symbol
LRP8provided by CGNC
Full Name
LDL receptor related protein 8provided by CGNC
Primary source
CGNC:49649
See related
Ensembl:ENSGALG00010025214
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
LR8B
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LRP8 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 8 NC_052539.1 (24349072..24499027, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 8 NC_052580.1 (24361344..24511340, complement)

Chromosome 8 - NC_052539.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124418131 Neighboring gene uncharacterized LOC121111420 Neighboring gene microRNA 1675 Neighboring gene mago homolog, exon junction complex core component Neighboring gene uncharacterized LOC121111422 Neighboring gene uncharacterized LOC121111423 Neighboring gene DMRT like family B with proline rich C-terminal 1 Neighboring gene uncharacterized LOC121111425 Neighboring gene uncharacterized LOC124418132

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Alternative splicing in the ligand binding domain of mouse ApoE receptor-2 produces receptor variants binding reelin but not alpha 2-macroglobulin. Brandes C, et al. J Biol Chem, 2001 Jun 22. PMID 11294845
  2. Multiple involvement of clusterin in chicken ovarian follicle development. Binding to two oocyte-specific members of the low density lipoprotein receptor gene family. Mahon MG, et al. J Biol Chem, 1999 Feb 12. PMID 9933595
  3. A new low density lipoprotein receptor homologue with 8 ligand binding repeats in brain of chicken and mouse. Novak S, et al. J Biol Chem, 1996 May 17. PMID 8662771
  4. The low density lipoprotein receptor gene family. Differential expression of two alpha2-macroglobulin receptors in the brain. Stockinger W, et al. J Biol Chem, 1998 Nov 27. PMID 9822699
  5. Reelin/DAB-1 signaling in the embryonic limb regulates the chondrogenic differentiation of digit mesodermal progenitors. Diaz-Mendoza MJ, et al. J Cell Physiol, 2014 Oct. PMID 24519818

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The expression of piRNA-linked gene LRP8 was increased after knockdown of piRNA-pathway gene PIWIL2, but not PIWIL1.
    Title: Small non-coding RNA profiling and the role of piRNA pathway genes in the protection of chicken primordial germ cells.
  2. ApoER2 transcripts are expressed in the digit cartilages. Reelin promotes chondrogenesis through ApoER2.
    Title: Reelin/DAB-1 signaling in the embryonic limb regulates the chondrogenic differentiation of digit mesodermal progenitors.
  3. Genotype of LRP8 is associated with egg-type layres from several chicken families.
    Title: Low-density lipoprotein receptor-related protein 8 gene association with egg traits in dwarf chickens.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
low-density lipoprotein receptor-related protein 8
Names
LRP-8
apolipoprotein E receptor 2
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205186.3 → NP_990517.2  low-density lipoprotein receptor-related protein 8 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000239
    UniProtKB/Swiss-Prot
    Q90883, Q98931
    UniProtKB/TrEMBL
    F1NS31
    Related
    ENSGALP00010038005.1, ENSGALT00010061524.1
    Conserved Domains (8) summary
    smart00192
    Location:187 → 219
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:504 → 545
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:391 → 421
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:352 → 383
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00112
    Location:149 → 183
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01456
    Location:754 → 807
    Mucin; Mucin-like glycoprotein
    cd05819
    Location:513 → 548
    NHL; NHL repeat [structural motif]
    cl18310
    Location:507 → 691
    NHL; NHL repeat unit of beta-propeller proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    24349072..24499027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046944254.1 → XP_046800210.1  low-density lipoprotein receptor-related protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZWP9, A0A8V1A471
    Related
    ENSGALP00010038001.1, ENSGALT00010061512.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    24361344..24511340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046922344.1 → XP_046778300.1  low-density lipoprotein receptor-related protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZWP9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q98931.1 GenPept UniProtKB/Swiss-Prot:Q98931

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials