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RET ret proto-oncogene [ Gallus gallus (chicken) ]

Gene ID: 396107, updated on 3-Dec-2024

Summary

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Symbol
RETprovided by CGNC
Full Name
ret proto-oncogeneprovided by CGNC
Primary source
CGNC:1837
See related
Ensembl:ENSGALG00010011131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See RET in Genome Data Viewer
Location:
chromosome: 6
Exon count:
26
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (5477834..5584430, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (5364542..5443960, complement)

Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene RasGEF domain family member 1A Neighboring gene microRNA mir-12280 Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 2 Neighboring gene uncharacterized LOC121111190 Neighboring gene paired box protein 6 homolog Neighboring gene BMS1, ribosome biogenesis factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The receptor tyrosine kinase RET regulates hindgut colonization by sacral neural crest cells. Delalande JM, et al. Dev Biol, 2008 Jan 1. PMID 18031721
  2. Expression of ret in the chicken embryo suggests roles in regionalisation of the vagal neural tube and somites and in development of multiple neural crest and placodal lineages. Robertson K, et al. Mech Dev, 1995 Nov. PMID 8645600
  3. RET overactivation leads to concurrent Hirschsprung disease and intestinal ganglioneuromas. Nagy N, et al. Development, 2020 Nov 5. PMID 32994173, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
proto-oncogene tyrosine-protein kinase receptor Ret
NP_990521.3
XP_040558213.1
XP_040558214.1
XP_040558215.1
XP_046775888.1
XP_046775889.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205190.3 → NP_990521.3  proto-oncogene tyrosine-protein kinase receptor Ret precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000227
    UniProtKB/TrEMBL
    Q90601
    Related
    ENSGALP00010015190.1, ENSGALT00010026638.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5477834..5584430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040702280.2 → XP_040558214.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y3L0
    Conserved Domains (2) summary
    cd05045
    Location:633 → 922
    PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
    smart00112
    Location:106 → 178
    CA; Cadherin repeats

  2. XM_040702279.2 → XP_040558213.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform X1

    UniProtKB/TrEMBL
    A0A8V0YGR1, Q9PSD4
    Related
    ENSGALP00010015192.1, ENSGALT00010026641.1
    Conserved Domains (3) summary
    cd05045
    Location:714 → 1003
    PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
    cd11304
    Location:26 → 94
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:187 → 259
    CA; Cadherin repeats

  3. XM_040702281.1 → XP_040558215.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y3L0
    Related
    ENSGALP00010015196.1, ENSGALT00010026645.1
    Conserved Domains (2) summary
    cd05045
    Location:633 → 922
    PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
    smart00112
    Location:106 → 178
    CA; Cadherin repeats

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    5364542..5443960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046919932.1 → XP_046775888.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform X1

    UniProtKB/TrEMBL
    Q9PSD4

  2. XM_046919933.1 → XP_046775889.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y3L0
Nucleotide Protein Strain
Heading Accession and Version

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