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Helz Helicase with zinc finger [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39613, updated on 4-Jan-2025

Summary

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Official Symbol
Helzprovided by FlyBase
Official Full Name
Helicase with zinc fingerprovided by FlyBase
Primary source
FLYBASE:FBgn0036451
Locus tag
Dmel_CG9425
See related
AllianceGenome:FB:FBgn0036451
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9425; Dmel\CG9425; HELZ
Summary
Predicted to enable RNA binding activity. Predicted to be involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be active in P granule and cytosol. Is expressed in adult head. Orthologous to human HELZ (helicase with zinc finger). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Helz in Genome Data Viewer
Location:
70F6-70F6; 3-42 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14789935..14801089)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14783035..14794189)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene brummer Neighboring gene Tudor domain containing 3 Neighboring gene NHP2 Neighboring gene giant nuclei

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs. Hanet A, et al. Life Sci Alliance, 2019 Oct. PMID 31570513, Free PMC Article
  2. A functional genomic screen for cardiogenic genes using RNA interference in developing Drosophila embryos. Kim YO, et al. Proc Natl Acad Sci U S A, 2004 Jan 6. PMID 14684833, Free PMC Article
  3. Genome-wide prediction of Polycomb/Trithorax response elements in Drosophila melanogaster. Ringrose L, et al. Dev Cell, 2003 Nov. PMID 14602076
  4. The Hippo signaling pathway interactome. Kwon Y, et al. Science, 2013 Nov 8. PMID 24114784, Free PMC Article
  5. In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor. Baker FC, et al. Development, 2021 Nov 15. PMID 35020877, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
helicase with zinc finger
Names
CG9425-PB
CG9425-PC
CG9425-PD
Helz-PB
Helz-PC
Helz-PD
NP_001261848.1
NP_648725.2
NP_996084.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14789935..14801089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206362.2 → NP_996084.1  helicase with zinc finger, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996084.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KUL0, Q9VUH9
    Conserved Domains (4) summary
    cd00009
    Location:810 → 886
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    TIGR00376
    Location:657 → 1236
    TIGR00376; DNA helicase, putative
    pfam00642
    Location:329 → 353
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13087
    Location:1003 → 1213
    AAA_12; AAA domain

  2. NM_001274919.2 → NP_001261848.1  helicase with zinc finger, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261848.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KUL0, Q9VUH9
    Conserved Domains (4) summary
    cd00009
    Location:810 → 886
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    TIGR00376
    Location:657 → 1236
    TIGR00376; DNA helicase, putative
    pfam00642
    Location:329 → 353
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13087
    Location:1003 → 1213
    AAA_12; AAA domain

  3. NM_140468.3 → NP_648725.2  helicase with zinc finger, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648725.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KUL0, Q9VUH9
    Conserved Domains (4) summary
    cd00009
    Location:810 → 886
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    TIGR00376
    Location:657 → 1236
    TIGR00376; DNA helicase, putative
    pfam00642
    Location:329 → 353
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13087
    Location:1003 → 1213
    AAA_12; AAA domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MR22 Q8MR22
Q9VUH9 Q9VUH9

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