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ROS1 ROS proto-oncogene 1, receptor tyrosine kinase [ Gallus gallus (chicken) ]

Gene ID: 396192, updated on 3-Dec-2024

Summary

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Symbol
ROS1provided by CGNC
Full Name
ROS proto-oncogene 1, receptor tyrosine kinaseprovided by CGNC
Primary source
CGNC:11070
See related
Ensembl:ENSGALG00010012360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See ROS1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
48
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (63161245..63244863)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (63020318..63103944)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene golgi associated PDZ and coiled-coil motif containing Neighboring gene uncharacterized LOC124417811 Neighboring gene discoidin, CUB and LCCL domain containing 1 Neighboring gene uncharacterized LOC101749120 Neighboring gene vestigial like family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chicken proto-oncogene c-ros cDNA clones: identification of a c-ros RNA transcript and deduction of the amino acid sequence of the carboxyl terminus of the c-ros product. Podell SB, et al. Oncogene, 1987. PMID 3325887
  2. Proto-oncogene c-ros codes for a molecule with structural features common to those of growth factor receptors and displays tissue specific and developmentally regulated expression. Neckameyer WS, et al. Mol Cell Biol, 1986 May. PMID 3023892, Free PMC Article
  3. The proto-oncogene c-ros codes for a transmembrane tyrosine protein kinase sharing sequence and structural homology with sevenless protein of Drosophila melanogaster. Chen JM, et al. Oncogene, 1991 Feb. PMID 1900358
  4. Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule. Matsushime H, et al. Mol Cell Biol, 1986 Aug. PMID 3023956, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
proto-oncogene tyrosine-protein kinase ROS
Names
ROS proto-oncogene 1 , receptor tyrosine kinase
c-Ros receptor tyrosine kinase
c-ros oncogene 1 , receptor tyrosine kinase
c-ros-1
proto-oncogene c-Ros
proto-oncogene c-Ros-1
receptor tyrosine kinase c-ros oncogene 1
v-ros UR2 sarcoma virus oncogene homolog 1
NP_990588.2
XP_046769180.1
XP_046769181.1
XP_046794483.1
XP_046794484.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205257.4 → NP_990588.2  proto-oncogene tyrosine-protein kinase ROS precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000065
    UniProtKB/Swiss-Prot
    P08941
    UniProtKB/TrEMBL
    F1NQL9
    Related
    ENSGALP00010017222.1, ENSGALT00010029602.1
    Conserved Domains (2) summary
    cd00063
    Location:572 → 668
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05044
    Location:1965 → 2234
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    63161245..63244863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046938527.1 → XP_046794483.1  proto-oncogene tyrosine-protein kinase ROS isoform X1

    UniProtKB/Swiss-Prot
    P08941
    UniProtKB/TrEMBL
    F1NQL9

  2. XM_046938528.1 → XP_046794484.1  proto-oncogene tyrosine-protein kinase ROS isoform X1

    UniProtKB/Swiss-Prot
    P08941
    UniProtKB/TrEMBL
    F1NQL9

RNA

  1. XR_005858072.2 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    63020318..63103944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046913224.1 → XP_046769180.1  proto-oncogene tyrosine-protein kinase ROS isoform X1

    UniProtKB/Swiss-Prot
    P08941
    UniProtKB/TrEMBL
    F1NQL9

  2. XM_046913225.1 → XP_046769181.1  proto-oncogene tyrosine-protein kinase ROS isoform X1

    UniProtKB/Swiss-Prot
    P08941
    UniProtKB/TrEMBL
    F1NQL9

RNA

  1. XR_006933914.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08941.3 GenPept UniProtKB/Swiss-Prot:P08941

Gene LinkOut

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