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SERPINH1 serpin family H member 1 [ Gallus gallus (chicken) ]

Gene ID: 396228, updated on 3-Dec-2024

Summary

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Official Symbol
SERPINH1provided by CGNC
Official Full Name
serpin family H member 1provided by CGNC
Primary source
CGNC:8518
See related
Ensembl:ENSGALG00010002923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
HSP47
Orthologs
human mouse all
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Genomic context

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See SERPINH1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
6
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (195370322..195377125, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (195237186..195244026, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD15 Neighboring gene small nucleolar RNA SNORD15 Neighboring gene uncharacterized LOC101751623 Neighboring gene ribosomal protein S3 Neighboring gene uncharacterized LOC121109258 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Heat shock protein 47 and 65-kDa FK506-binding protein weakly but synergistically interact during collagen folding in the endoplasmic reticulum. Ishikawa Y, et al. J Biol Chem, 2017 Oct 20. PMID 28860186, Free PMC Article
  2. Characterization of a novel transformation-sensitive heat-shock protein (HSP47) that binds to collagen. Nagata K, et al. Biochem Biophys Res Commun, 1988 May 31. PMID 3377793
  3. HSP47: a tissue-specific, transformation-sensitive, collagen-binding heat shock protein of chicken embryo fibroblasts. Hirayoshi K, et al. Mol Cell Biol, 1991 Aug. PMID 2072906, Free PMC Article
  4. Conserved BK channel-protein interactions reveal signals relevant to cell death and survival. Sokolowski B, et al. PLoS One, 2011. PMID 22174833, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that a weak interaction between Hsp47 and FKBP65 confers mutual molecular stability and also allows for a synergistic effect during collagen folding.
    Title: Heat shock protein 47 and 65-kDa FK506-binding protein weakly but synergistically interact during collagen folding in the endoplasmic reticulum.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables collagen binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen fibril organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serpin H1
Names
47 kDa heat shock protein
collagen-binding protein
colligin
heat shock protein 47
serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396972.1 → NP_001383901.1  serpin H1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000032
    UniProtKB/Swiss-Prot
    P13731, P29042
    UniProtKB/TrEMBL
    A0A8V0XBU4

  2. NM_205291.2 → NP_990622.1  serpin H1 precursor

    See identical proteins and their annotated locations for NP_990622.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000032
    UniProtKB/Swiss-Prot
    P13731, P29042
    UniProtKB/TrEMBL
    A0A8V0XBU4
    Related
    ENSGALP00010004137.1, ENSGALT00010006788.1
    Conserved Domains (1) summary
    cd02046
    Location:23 → 404
    serpinH1_CBP1; serpin family H member 1, collagen-binding protein 1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    195370322..195377125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040665757.2 → XP_040521691.1  serpin H1 isoform X1

    UniProtKB/Swiss-Prot
    P13731, P29042
    UniProtKB/TrEMBL
    A0A8V0XBU4
    Conserved Domains (1) summary
    cd02046
    Location:23 → 404
    serpinH1_CBP1; serpin family H member 1, collagen-binding protein 1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    195237186..195244026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906875.1 → XP_046762831.1  serpin H1 isoform X1

    UniProtKB/Swiss-Prot
    P13731, P29042
    UniProtKB/TrEMBL
    A0A8V0XBU4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13731.2 GenPept UniProtKB/Swiss-Prot:P13731

Gene LinkOut

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