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mRpL39 mitochondrial ribosomal protein L39 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39627, updated on 9-Dec-2024

Summary

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Official Symbol
mRpL39provided by FlyBase
Official Full Name
mitochondrial ribosomal protein L39provided by FlyBase
Primary source
FLYBASE:FBgn0036462
Locus tag
Dmel_CG17166
See related
AllianceGenome:FB:FBgn0036462
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17166; Dmel\CG17166; MRP-L5; mRpL5
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; gut section; and mesoderm. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human MRPL39 (mitochondrial ribosomal protein L39). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See mRpL39 in Genome Data Viewer
Location:
71B1-71B1; 3-42 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14997981..14999666, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14991081..14992766, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene minidiscs Neighboring gene Zinc/iron regulated transporter-related protein 71B Neighboring gene Proteasome beta2 subunit Neighboring gene Reversion-inducing-cysteine-rich protein with kazal motifs Neighboring gene Synaptotagmin beta Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Ishizuka A, et al. Genes Dev, 2002 Oct 1. PMID 12368261, Free PMC Article
  2. Genome-Wide Analysis of Drosophila RBf2 Protein Highlights the Diversity of RB Family Targets and Possible Role in Regulation of Ribosome Biosynthesis. Wei Y, et al. G3 (Bethesda), 2015 May 20. PMID 25999584, Free PMC Article
  3. Cardiomyopathy is associated with ribosomal protein gene haplo-insufficiency in Drosophila melanogaster. Casad ME, et al. Genetics, 2011 Nov. PMID 21890737, Free PMC Article
  4. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. Suzuki T, et al. J Biol Chem, 2001 Jun 15. PMID 11279069
  5. A genomic switch at the transition from cell proliferation to terminal differentiation in the Drosophila eye. Jasper H, et al. Dev Cell, 2002 Oct. PMID 12408803

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of mitochondrial large ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mitochondrial large ribosomal subunit TAS
Traceable Author Statement
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitochondrial ribosomal protein L39
Names
CG17166-PA
mRpL39-PA
mitochondrial ribosomal protein L5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14997981..14999666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079351.4 → NP_524075.2  mitochondrial ribosomal protein L39 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524075.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SYN5, Q9VUJ0
    UniProtKB/TrEMBL
    G2J631
    Related
    FBpp0075425
    Conserved Domains (1) summary
    cd01667
    Location:65 → 123
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VUJ0.2 Q9VUJ0

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