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INCENP inner centromere protein [ Gallus gallus (chicken) ]

Gene ID: 396270, updated on 3-Dec-2024

Summary

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Symbol
INCENPprovided by CGNC
Full Name
inner centromere proteinprovided by CGNC
Primary source
CGNC:5686
See related
Ensembl:ENSGALG00010025358
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See INCENP in Genome Data Viewer
Location:
chromosome: 5
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (16641309..16665102)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (16601623..16625538)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 55 Neighboring gene inner centromere protein antigens 135/155kDa-like Neighboring gene microRNA 1802 Neighboring gene two pore segment channel 2 Neighboring gene uncharacterized LOC107053438

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis. Samejima K, et al. J Biol Chem, 2015 Aug 28. PMID 26175154, Free PMC Article
  2. Molecular analysis of the INCENPs (inner centromere proteins): separate domains are required for association with microtubules during interphase and with the central spindle during anaphase. Mackay AM, et al. J Cell Biol, 1993 Oct. PMID 8408220, Free PMC Article
  3. INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Wheatley SP, et al. Curr Biol, 2001 Jun 5. PMID 11516652
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the central region (213 residues) of chicken INCENP is not a coiled coil but a approximately 32-nm-long single alpha-helix (SAH) domain.
    Title: The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in meiotic spindle midzone assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in metaphase chromosome alignment IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of chromosome passenger complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in meiotic spindle midzone IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in midbody IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
inner centromere protein
Names
class I INCENP protein
class II INCENP protein
inner centromere protein antigens 135/155kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205330.1 → NP_990661.1  inner centromere protein

    See identical proteins and their annotated locations for NP_990661.1

    Status: PROVISIONAL

    Source sequence(s)
    Z25419
    UniProtKB/TrEMBL
    A0A8V1A4Y8
    Related
    ENSGALP00010038250.1, ENSGALT00010061949.1
    Conserved Domains (4) summary
    pfam03941
    Location:752 → 803
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:5 → 40
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    cd16269
    Location:646 → 657
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:576 → 659
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    16641309..16665102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015286759.4 → XP_015142245.2  inner centromere protein isoform X1

    UniProtKB/Swiss-Prot
    P53352
    Conserved Domains (2) summary
    PTZ00121
    Location:503 → 764
    PTZ00121; MAEBL; Provisional
    cl08110
    Location:723 → 821
    DUF2756; Protein of unknown function (DUF2756)

  2. XM_046941485.1 → XP_046797441.1  inner centromere protein isoform X1

    UniProtKB/Swiss-Prot
    P53352
    Related
    ENSGALP00010038257.1, ENSGALT00010061960.1

  3. XM_015286760.4 → XP_015142246.2  inner centromere protein isoform X2

    UniProtKB/TrEMBL
    A0A8V1A4Y8, A0A8V1AA26
    Conserved Domains (1) summary
    PTZ00121
    Location:503 → 712
    PTZ00121; MAEBL; Provisional

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    16601623..16625538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917910.1 → XP_046773866.1  inner centromere protein isoform X1

    UniProtKB/Swiss-Prot
    P53352

  2. XM_046917911.1 → XP_046773867.1  inner centromere protein isoform X1

    UniProtKB/Swiss-Prot
    P53352

  3. XM_046917912.1 → XP_046773868.1  inner centromere protein isoform X2

    UniProtKB/TrEMBL
    A0A8V1A4Y8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53352.1 GenPept UniProtKB/Swiss-Prot:P53352

Gene LinkOut

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