ALPL alkaline phosphatase, biomineralization associated [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: ALPLprovided by CGNC
Official Full Name: alkaline phosphatase, biomineralization associatedprovided by CGNC
Primary source: CGNC:49750
See related: Ensembl:ENSGALG00010021115
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	21	NC_052552.1 (6585122..6593050, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	21	NC_052593.1 (6620143..6627925, complement)

Chromosome 21 - NC_052552.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cooperative functions of ZnT1, metallothionein and ZnT4 in the cytoplasm are required for full activation of TNAP in the early secretory pathway.
Title: Cooperative functions of ZnT1, metallothionein and ZnT4 in the cytoplasm are required for full activation of TNAP in the early secretory pathway.
Tissue-nonspecific alkaline phosphatase (in matrix vesicles of chick embryos) is inhibited by lansoprazole (a noncompetitive inhibitor).
Title: Lansoprazole is an uncompetitive inhibitor of tissue-nonspecific alkaline phosphatase.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables alkaline phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: alkaline phosphatase, tissue-nonspecific isozyme

Names: AP-TNAP; TNSALP; alkaline phosphatase, liver/bone/kidney; phosphoamidase; tissue-nonspecific alkaline phosphatase

NP_990691.2

EC 3.1.3.1

XP_046759065.1

EC 3.1.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205360.2 → NP_990691.2 alkaline phosphatase, tissue-nonspecific isozyme precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000329

UniProtKB/Swiss-Prot

Q92058

UniProtKB/TrEMBL

F1NN44

Related

ENSGALP00010030303.1, ENSGALT00010051112.1

Conserved Domains (1) summary

smart00098
Location:51 → 490

alkPPc; Alkaline phosphatase homologues

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052552.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

6585122..6593050 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)