IL8L2 interleukin 8-like 2 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: IL8L2provided by CGNC
Official Full Name: interleukin 8-like 2provided by CGNC
Primary source: CGNC:49835
See related: Ensembl:ENSGALG00010005131
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: IL8; CEF4; EMF1; CXCL8; EMF-1; CXCLi2
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Genomic context

Location:: chromosome: 4

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (50443423..50446598)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (50447444..50450618)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study of the Relationship between Polymorphisms in the IL-8 Gene Promoter Region and Coccidiosis Resistance Index in Jinghai Yellow Chickens.
Title: Study of the Relationship between Polymorphisms in the IL-8 Gene Promoter Region and Coccidiosis Resistance Index in Jinghai Yellow Chickens.
Lower levels in airway aspirates from breastfed infants with acute bronchiolitis
Title: Lower interleukin-8 levels in airway aspirates from breastfed infants with acute bronchiolitis.
Authors use expression of pro-inflammatory cytokines IL1b, IL8 and CCL4/K203 to demonstrate development of innate immunity in hatchling's gut
Title: Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick.
CXCLi1 (K60) and CXCLi2 (CAF/interleukin-8) look equally like orthologues of human CXCL8 and are ligands for chicken CXCR1
Title: Re-evaluation of chicken CXCR1 determines the true gene structure: CXCLi1 (K60) and CXCLi2 (CAF/interleukin-8) are ligands for this receptor.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables CXCR chemokine receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables chemokine activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-8

Names: 9E3; C-X-C motif chemokine 8; CEF-4; CEF-4/9E3 cytokine; IL-8; RSV-induced protein; chemokine (C-X-C motif) ligand 8; embryo fibroblast protein 1; putatitve interleukin-8; transformation-induced protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205498.2 → NP_990829.1 interleukin-8 precursor

See identical proteins and their annotated locations for NP_990829.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000074

UniProtKB/Swiss-Prot

P08317, Q546U2

UniProtKB/TrEMBL

A3DTN6

Related

ENSGALP00010006734.1, ENSGALT00010012069.1

Conserved Domains (1) summary

cd00273
Location:30 → 93

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...