U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TXNRD1 thioredoxin reductase 1 [ Sus scrofa (pig) ]

Gene ID: 396681, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
TXNRD1provided by VGNC
Official Full Name
thioredoxin reductase 1provided by VGNC
Primary source
VGNC:VGNC:109419
See related
Ensembl:ENSSSCG00000000843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
TRXR1
Expression
Ubiquitous expression in ovary (RPKM 33.9), kidney (RPKM 24.3) and 8 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TXNRD1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
13
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 5 NC_010447.5 (80170334..80213889, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 5 NC_010447.4 (83657828..83701655)

Chromosome 5 - NC_010447.5Genomic Context describing neighboring genes Neighboring gene solute carrier family 41 member 2 Neighboring gene uncharacterized LOC110260779 Neighboring gene carbohydrate sulfotransferase 11 Neighboring gene transfer RNA alanine (anticodon UGC) Neighboring gene EP300 interacting inhibitor of differentiation 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Effect of selenium intake and fetal age on mRNA levels of two selenoproteins in porcine fetal and maternal liver. Hostetler CE, et al. J Anim Sci, 2006 Sep. PMID 16908641
  2. Genomic changes in regenerated porcine coronary arterial endothelial cells. Lee MY, et al. Arterioscler Thromb Vasc Biol, 2007 Nov. PMID 17942849
  3. Exclusion of NFYB as candidate gene for congenital splay leg in piglets and radiation hybrid mapping of further five homologous porcine genes from human chromosome 12 (HSA12). Boettcher D, et al. Cytogenet Genome Res, 2007. PMID 17901702
  4. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  5. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. regenerated coronary endothelial cells exhibit downregulation of thioredoxin reductase
    Title: Genomic changes in regenerated porcine coronary arterial endothelial cells.
  2. The developmental expression of cytosolic glutathione peroxidase and TRXR1 during fetal development and the effect of maternal selenium consumption on the expression of these proteins are reported.
    Title: Effect of selenium intake and fetal age on mRNA levels of two selenoproteins in porcine fetal and maternal liver.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glutathione-disulfide reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables thioredoxin-disulfide reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
thioredoxin reductase 1, cytoplasmic
Names
TR
peroxidase TXNRD1
redox enzyme thioredoxin reductase
thioredoxin reductase TR1
NP_999319.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214154.3 → NP_999319.2  thioredoxin reductase 1, cytoplasmic

    Status: VALIDATED

    Source sequence(s)
    AF537300, BF711134, BW983330, BW983647, CJ029416, DB784010, FP565370
    UniProtKB/TrEMBL
    A0A8D1IWN6
    Related
    ENSSSCP00000073127.2, ENSSSCT00000074845.2
    Conserved Domains (3) summary
    TIGR01438
    Location:11 → 499
    TGR; thioredoxin and glutathione reductase selenoprotein
    pfam00070
    Location:192 → 262
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:371 → 481
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010447.5 Reference Sscrofa11.1 Primary Assembly

    Range
    80170334..80213889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9MYY8.3 GenPept UniProtKB/Swiss-Prot:Q9MYY8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials