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CG7857 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39671, updated on 4-Jan-2025

Summary

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Official Symbol
CG7857provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0026738
Locus tag
Dmel_CG7857
See related
AllianceGenome:FB:FBgn0026738
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-Becker1; Dmel\CG7857; Q9VUN9
Summary
Enables cysteine-type deubiquitinase activity. Involved in positive regulation of translational initiation in response to stress. Located in cytosol and nucleolus. Orthologous to human OTUD6A (OTU deubiquitinase 6A) and OTUD6B (OTU deubiquitinase 6B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG7857 in Genome Data Viewer
Location:
71D3-71D3; 3-43 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15503600..15504894, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15496700..15497994, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene gdl-ORF39 Neighboring gene Z600 Neighboring gene gonadal

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. OTUD6 deubiquitination of RPS7/eS7 on the free 40 S ribosome regulates global protein translation and stress. Villa S, et al. Nat Commun, 2024 Aug 11. PMID 39127721, Free PMC Article
  2. Prp8 regulates oncogene-induced hyperplastic growth in Drosophila. Fernández-Espartero CH, et al. Development, 2018 Nov 12. PMID 30333215, Free PMC Article
  3. Deubiquitylases from genes to organism. Clague MJ, et al. Physiol Rev, 2013 Jul. PMID 23899565
  4. Systematic analysis of the physiological importance of deubiquitinating enzymes. Tsou WL, et al. PLoS One, 2012. PMID 22937016, Free PMC Article
  5. Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster. Páhi ZG, et al. Sci Rep, 2022 Apr 7. PMID 35393473, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of translational initiation in response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleolus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG7857-PA
NP_648769.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15503600..15504894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140512.2 → NP_648769.2  uncharacterized protein Dmel_CG7857 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648769.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRW3, Q9VUN9
    Related
    FBpp0075358, FBtr0075605
    Conserved Domains (2) summary
    COG5539
    Location:17 → 307
    COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    pfam02338
    Location:178 → 305
    OTU; OTU-like cysteine protease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRW3 Q8MRW3
Q9VUN9 Q9VUN9
Q9XYY2 Q9XYY2

Gene LinkOut

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