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SCCRO Squamous cell carcinoma-related oncogene [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39685, updated on 9-Dec-2024

Summary

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Official Symbol
SCCROprovided by FlyBase
Official Full Name
Squamous cell carcinoma-related oncogeneprovided by FlyBase
Primary source
FLYBASE:FBgn0036510
Locus tag
Dmel_CG7427
See related
AllianceGenome:FB:FBgn0036510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7427; Dmel\CG7427; dSCCRO; Sccro
Summary
Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Involved in cell competition in a multicellular organism and positive regulation of protein neddylation. Located in nucleus. Is expressed in embryonic/larval garland cell and organism. Orthologous to human DCUN1D1 (defective in cullin neddylation 1 domain containing 1) and DCUN1D2 (defective in cullin neddylation 1 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See SCCRO in Genome Data Viewer
Location:
71E1-71E1; 3-43 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15563427..15565559)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15556527..15558659)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cyclic-AMP response element binding protein A Neighboring gene Argonaute 2 Neighboring gene uncharacterized protein Neighboring gene drop out Neighboring gene UFM1 specific peptidase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Squamous Cell Carcinoma-related Oncogene (SCCRO) Family Members Regulate Cell Growth and Proliferation through Their Cooperative and Antagonistic Effects on Cullin Neddylation. Fu W, et al. J Biol Chem, 2016 Mar 18. PMID 26792857, Free PMC Article
  2. Mechanisms of cell competition emerging from Drosophila studies. Baker NE. Curr Opin Cell Biol, 2017 Oct. PMID 28600967, Free PMC Article
  3. Emerging mechanisms of cell competition. Baker NE. Nat Rev Genet, 2020 Nov. PMID 32778819, Free PMC Article
  4. A set of structural features defines the cis-regulatory modules of antenna-expressed genes in Drosophila melanogaster. López Y, et al. PLoS One, 2014. PMID 25153327, Free PMC Article
  5. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell competition in a multicellular organism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein neddylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein neddylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
squamous cell carcinoma-related oncogene
Names
CG7427-PA
CG7427-PB
CG7427-PC
CG7427-PD
CG7427-PE
SCCRO-PA
SCCRO-PB
SCCRO-PC
SCCRO-PD
SCCRO-PE
squamous cell carcinoma-related oncogene ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15563427..15565559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140520.4 → NP_648777.1  squamous cell carcinoma-related oncogene, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648777.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VUQ8
    UniProtKB/TrEMBL
    D4G7B4, M9PI67
    Related
    FBpp0075314
    Conserved Domains (2) summary
    pfam03556
    Location:132 → 243
    Cullin_binding; Cullin binding
    cl21463
    Location:2 → 49
    UBA_like_SF; UBA domain-like superfamily

  2. NM_001259841.2 → NP_001246770.1  squamous cell carcinoma-related oncogene, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246770.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D4G7B4, M9NDR9
    Conserved Domains (2) summary
    pfam03556
    Location:141 → 252
    Cullin_binding; Cullin binding
    cl21463
    Location:11 → 58
    UBA_like_SF; UBA domain-like superfamily

  3. NM_001259840.2 → NP_001246769.1  squamous cell carcinoma-related oncogene, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246769.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D4G7B4, M9NEA3
    Conserved Domains (2) summary
    pfam03556
    Location:135 → 246
    Cullin_binding; Cullin binding
    cl21463
    Location:5 → 52
    UBA_like_SF; UBA domain-like superfamily

  4. NM_001259842.2 → NP_001246771.1  squamous cell carcinoma-related oncogene, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246771.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D4G7B4, M9NEA3
    Conserved Domains (2) summary
    pfam03556
    Location:135 → 246
    Cullin_binding; Cullin binding
    cl21463
    Location:5 → 52
    UBA_like_SF; UBA domain-like superfamily

  5. NM_001274954.1 → NP_001261883.1  squamous cell carcinoma-related oncogene, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261883.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VUQ8
    UniProtKB/TrEMBL
    D4G7B4, M9PI67
    Conserved Domains (2) summary
    pfam03556
    Location:132 → 243
    Cullin_binding; Cullin binding
    cl21463
    Location:2 → 49
    UBA_like_SF; UBA domain-like superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NDR9 M9NDR9
M9NEA3 M9NEA3
M9PI67 M9PI67
Q9VUQ8.2 Q9VUQ8

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