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Ufsp2 UFM1 specific peptidase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39687, updated on 4-Jan-2025

Summary

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Official Symbol
Ufsp2provided by FlyBase
Official Full Name
UFM1 specific peptidase 2provided by FlyBase
Primary source
FLYBASE:FBgn0036512
Locus tag
Dmel_CG16979
See related
AllianceGenome:FB:FBgn0036512
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG16979; Dmel\CG16979; UfSP2
Summary
Predicted to enable deUFMylase activity. Predicted to be involved in proteolysis. Located in endomembrane system. Is expressed in adult head; embryonic/larval salivary gland; and organism. Human ortholog(s) of this gene implicated in Beukes hip dysplasia and developmental and epileptic encephalopathy 106. Orthologous to human UFSP2 (UFM1 specific peptidase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ufsp2 in Genome Data Viewer
Location:
71E1-71E1; 3-43 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15576570..15578674)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15569670..15571774)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Squamous cell carcinoma-related oncogene Neighboring gene drop out Neighboring gene marionette Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. Kang SH, et al. J Biol Chem, 2007 Feb 23. PMID 17182609
  2. Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster. Dembeck LM, et al. Elife, 2015 Nov 14. PMID 26568309, Free PMC Article
  3. In vivo RNAi screening identifies multiple deubiquitinases required for the maintenance of intestinal homeostasis in Drosophila. Zhao B, et al. Insect Biochem Mol Biol, 2024 Sep. PMID 39067716
  4. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. den Hoed M, et al. Nat Genet, 2013 Jun. PMID 23583979, Free PMC Article
  5. Identification of genes associated with resilience/vulnerability to sleep deprivation and starvation in Drosophila. Thimgan MS, et al. Sleep, 2015 May 1. PMID 25409104, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables deUFMylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deUFMylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UFM1 specific peptidase 2
Names
CG16979-PA
Ufsp2-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15576570..15578674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140522.3 → NP_648779.1  UFM1 specific peptidase 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648779.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VUR0
    Related
    FBpp0075316
    Conserved Domains (1) summary
    pfam07910
    Location:414 → 599
    Peptidase_C78; Peptidase family C78
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VUR0.1 Q9VUR0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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