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AIMP2 aaRS-interacting multifunctional protein 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39690, updated on 4-Jan-2025

Summary

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Official Symbol
AIMP2provided by FlyBase
Official Full Name
aaRS-interacting multifunctional protein 2provided by FlyBase
Primary source
FLYBASE:FBgn0036515
Locus tag
Dmel_CG12304
See related
AllianceGenome:FB:FBgn0036515
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12304; Dmel\CG12304; p38
Summary
Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; gut section; and head mesoderm. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 17. Orthologous to human AIMP2 (aminoacyl tRNA synthetase complex interacting multifunctional protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See AIMP2 in Genome Data Viewer
Location:
71E1-71E1; 3-43 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15583638..15585347)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15576738..15578447)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene marionette Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rho GTPase activating protein at 71E Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The 18S ribosomal RNA m(6) A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. Leismann J, et al. EMBO Rep, 2020 Jul 3. PMID 32350990, Free PMC Article
  2. The aminoacyl-tRNA synthetases of Drosophila melanogaster. Lu J, et al. Fly (Austin), 2015. PMID 26761199, Free PMC Article
  3. Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae. Ranson H, et al. Biochem J, 2001 Oct 15. PMID 11583575, Free PMC Article
  4. Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation. Nie M, et al. PLoS One, 2009 Jun 16. PMID 19529778, Free PMC Article
  5. Discovery and Visualization of Age-Dependent Patterns in the Diurnal Transcriptome of Drosophila. Sebastian B, et al. J Circadian Rhythms, 2022. PMID 36561348, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of aminoacyl-tRNA synthetase multienzyme complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aaRS-interacting multifunctional protein 2
Names
AIMP2-PA
AIMP2-PB
CG12304-PA
CG12304-PB
aminoacyl-tRNA synthetase-interacting multifunctional protein 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15583638..15585347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140525.4 → NP_648782.2  aaRS-interacting multifunctional protein 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648782.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VUR3
    UniProtKB/TrEMBL
    E4NKL6
    Related
    FBpp0075318
    Conserved Domains (1) summary
    cd00299
    Location:275 → 327
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  2. NM_206375.3 → NP_996097.1  aaRS-interacting multifunctional protein 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996097.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NKM4, Q7KUM5, Q8T060
    Conserved Domains (1) summary
    cd00299
    Location:242 → 294
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T060 Q8T060
Q9VUR3.1 Q9VUR3

Gene LinkOut

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