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KPNA2 karyopherin subunit alpha 2 [ Sus scrofa (pig) ]

Gene ID: 397218, updated on 17-Aug-2024

Summary

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Official Symbol
KPNA2provided by VGNC
Official Full Name
karyopherin subunit alpha 2provided by VGNC
Primary source
VGNC:VGNC:89561
See related
Ensembl:ENSSSCG00000029005
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in ovary (RPKM 54.6), spleen (RPKM 41.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See KPNA2 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 12 NC_010454.4 (14283092..14296749)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003540521.1 (23..1809, complement)

Chromosome 12 - NC_010454.4Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene chromosome 12 C17orf58 homolog Neighboring gene transfer RNA arginine (anticodon CCG) Neighboring gene SMAD specific E3 ubiquitin protein ligase 2 Neighboring gene centrosomal protein 95

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. A crucial role of N-terminal domain of influenza A virus M1 protein in interaction with swine importin α1 protein. Liu Q, et al. Virus Genes, 2014 Aug. PMID 24743939, Free PMC Article
  2. Identification of karyopherin α1 and α7 interacting proteins in porcine tissue. Park KE, et al. PLoS One, 2012. PMID 22720010, Free PMC Article
  3. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Authors demonstrated that swine importin alpha1 interacts with the M1 protein and transports it to the nucleus.
    Title: A crucial role of N-terminal domain of influenza A virus M1 protein in interaction with swine importin α1 protein.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear localization sequence binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
importin subunit alpha-1
Names
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163404.1 → NP_001156876.1  importin subunit alpha-1

    See identical proteins and their annotated locations for NP_001156876.1

    Status: PROVISIONAL

    Source sequence(s)
    GQ166956
    UniProtKB/TrEMBL
    A0A8D0P9S6, C6K7I0
    Related
    ENSSSCP00000043346.3, ENSSSCT00000040768.3
    Conserved Domains (5) summary
    COG5064
    Location:10 → 528
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:113 → 238
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:10 → 98
    IBB; Importin beta binding domain
    pfam16186
    Location:458 → 508
    Arm_3; Atypical Arm repeat
    sd00043
    Location:253 → 278
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010454.4 Reference Sscrofa11.1 Primary Assembly

    Range
    14283092..14296749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021066215.1 → XP_020921874.1  importin subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    A0A4X1SWR0, A0A8D0P9S6, A0A8D0SF82, I3LS70
    Related
    ENSSSCP00000026961.2, ENSSSCT00000022690.4
    Conserved Domains (2) summary
    sd00043
    Location:253 → 278
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:10 → 528
    Arm_3; Atypical Arm repeat
Nucleotide Protein
Heading Accession and Version

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