CLCA1 chloride channel accessory 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: CLCA1provided by VGNC
Official Full Name: chloride channel accessory 1provided by VGNC
Primary source: VGNC:VGNC:86722
See related: Ensembl:ENSSSCG00000006933
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: AECC
Expression: Biased expression in lung (RPKM 31.3) and mixtures (RPKM 8.2) See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	4	NC_010446.5 (129621259..129655385, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	4	NC_010446.4 (142139255..142173314, complement)

Chromosome 4 - NC_010446.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

pCLCA1 shares essential characteristics of hCLCA1, supporting the pig model as a promising tool for studying the modulating role of pCLCA1 in the complex pathology of cystic fibrosis.
Title: Genomic, tissue expression, and protein characterization of pCLCA1, a putative modulator of cystic fibrosis in the pig.
pCLCA1 expression may increase the sensitivity of preexisting endogenous Cl(-) channels to Ca(2+) and cAMP agonists but apparently lacks inherent Cl(-) channel activity under growth conditions where endogenous channels are not expressed
Title: pCLCA1 lacks inherent chloride channel activity in an epithelial colon carcinoma cell line.

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General gene information

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Markers

ksks102 (e-PCR)
- UniSTS:514124

MARC_23881-23882:1031667917:3 (e-PCR)
- UniSTS:268788

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables intracellularly calcium-gated chloride channel activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in chloride transport	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: calcium-activated chloride channel regulator 1

Names: calcium-activated chloride channel family member 1; epithelial chloride channel protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214148.3 → NP_999313.2 calcium-activated chloride channel regulator 1 precursor

Status: VALIDATED

Source sequence(s)

AEMK02000025

UniProtKB/TrEMBL

A0A287A0E9, A0A8D0LYA1, A0A8D0VK45, A0A8D1G8L9

Related

ENSSSCP00000037372.1, ENSSSCT00000047623.2

Conserved Domains (1) summary

pfam08434
Location:25 → 911

CLCA; Calcium-activated chloride channel