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pHCl-1 pH-sensitive chloride channel 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39730, updated on 4-Jan-2025

Summary

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Official Symbol
pHCl-1provided by FlyBase
Official Full Name
pH-sensitive chloride channel 1provided by FlyBase
Primary source
FLYBASE:FBgn0264908
Locus tag
Dmel_CG44099
See related
AllianceGenome:FB:FBgn0264908
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH21757; BP1024; CG12486; CG13444; CG33989; CG44099; CG6112; CT19189; Dmel\CG44099; pHCl; pHCL-A
Old locus tag
Dmel_CG12486; Dmel_CG33989
Summary
Enables pH-gated chloride channel activity. Involved in chloride transmembrane transport. Located in membrane. Is expressed in several structures, including adult central brain; adult gut; adult optic lobe; adult ventral nerve cord; and organism subdivision. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See pHCl-1 in Genome Data Viewer
Location:
72A2-72A4; 3-43 cM
Exon count:
21
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15848578..15899029, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15841678..15892129, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-263b stem loop Neighboring gene meru Neighboring gene long non-coding RNA:CR44051 Neighboring gene long non-coding RNA:CR44050 Neighboring gene sugar-free frosting Neighboring gene Protein kinase, cAMP-dependent, catalytic subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The orphan pentameric ligand-gated ion channel pHCl-2 is gated by pH and regulates fluid secretion in Drosophila Malpighian tubules. Feingold D, et al. J Exp Biol, 2016 Sep 1. PMID 27358471
  2. Motivation, Perception, and Chance Converge to Make a Binary Decision. Zhang SX, et al. Neuron, 2018 Jul 25. PMID 29983326, Free PMC Article
  3. A novel chloride channel in Drosophila melanogaster is inhibited by protons. Schnizler K, et al. J Biol Chem, 2005 Apr 22. PMID 15713676
  4. Putative histamine-gated chloride channel subunits of the insect visual system and thoracic ganglion. Witte I, et al. J Neurochem, 2002 Nov. PMID 12390512
  5. Evolution, Expression, and Function of Nonneuronal Ligand-Gated Chloride Channels in Drosophila melanogaster. Remnant EJ, et al. G3 (Bethesda), 2016 Jul 7. PMID 27172217, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data implicate pHCl-2 as an important source of chloride conductance required for proper urine production.
    Title: The orphan pentameric ligand-gated ion channel pHCl-2 is gated by pH and regulates fluid secretion in Drosophila Malpighian tubules.
  2. new branch of ligand-gated ion channels in invertebrates
    Title: A novel chloride channel in Drosophila melanogaster is inhibited by protons.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables pH-gated chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pH-sensitive chloride channel 1
Names
CG44099-PC
CG44099-PD
CG44099-PE
CG44099-PF
CG44099-PG
CG44099-PH
CG44099-PI
CG44099-PJ
CG44099-PK
CG44099-PL
CG44099-PM
CG44099-PN
CG44099-PO
CG44099-PP
CG44099-PS
CG44099-PT
CG44099-PU
glutamate-gated chloride channel-like
pH-sensitive chloride channel
pHCl
pHCl-1-PC
pHCl-1-PD
pHCl-1-PE
pHCl-1-PF
pHCl-1-PG
pHCl-1-PH
pHCl-1-PI
pHCl-1-PJ
pHCl-1-PK
pHCl-1-PL
pHCl-1-PM
pHCl-1-PN
pHCl-1-PO
pHCl-1-PP
pHCl-1-PS
pHCl-1-PT
pHCl-1-PU

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15848578..15899029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274967.1 → NP_001261896.1  pH-sensitive chloride channel 1, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261896.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFR7
    Conserved Domains (3) summary
    TIGR00860
    Location:332 → 743
    LIC; Cation transporter family protein
    pfam02931
    Location:331 → 534
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:546 → 740
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  2. NM_001274969.1 → NP_001261898.1  pH-sensitive chloride channel 1, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261898.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PI70
    Conserved Domains (2) summary
    pfam02931
    Location:338 → 566
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:578 → 682
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  3. NM_001370026.1 → NP_001356909.1  pH-sensitive chloride channel 1, isoform U [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JGQ0
    Conserved Domains (1) summary
    TIGR00860
    Location:332 → 751
    LIC; Cation transporter family protein

  4. NM_001274966.1 → NP_001261895.1  pH-sensitive chloride channel 1, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261895.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFD4
    Conserved Domains (3) summary
    TIGR00860
    Location:332 → 742
    LIC; Cation transporter family protein
    pfam02931
    Location:331 → 534
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:546 → 739
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  5. NM_001370024.1 → NP_001356981.1  pH-sensitive chloride channel 1, isoform S [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4D6K8E5
    Conserved Domains (1) summary
    TIGR00860
    Location:332 → 768
    LIC; Cation transporter family protein

  6. NM_001274965.1 → NP_001261894.1  pH-sensitive chloride channel 1, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261894.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCN0
    Conserved Domains (3) summary
    TIGR00860
    Location:332 → 768
    LIC; Cation transporter family protein
    pfam02931
    Location:331 → 559
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:571 → 765
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  7. NM_001259853.1 → NP_001246782.1  pH-sensitive chloride channel 1, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246782.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFY2
    Conserved Domains (3) summary
    TIGR00860
    Location:339 → 750
    LIC; Cation transporter family protein
    pfam02931
    Location:338 → 541
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:553 → 747
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  8. NM_001259852.1 → NP_001246781.1  pH-sensitive chloride channel 1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246781.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NEB0
    Conserved Domains (3) summary
    TIGR00860
    Location:339 → 758
    LIC; Cation transporter family protein
    pfam02931
    Location:338 → 566
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:578 → 755
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  9. NM_001370025.1 → NP_001356910.1  pH-sensitive chloride channel 1, isoform T [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JCG3
    Conserved Domains (1) summary
    TIGR00860
    Location:339 → 766
    LIC; Cation transporter family protein

  10. NM_001038934.4 → NP_001034023.2  pH-sensitive chloride channel 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001034023.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUV2
    Conserved Domains (3) summary
    TIGR00860
    Location:339 → 733
    LIC; Cation transporter family protein
    pfam02931
    Location:338 → 541
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:553 → 730
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  11. NM_001038936.4 → NP_001034025.2  pH-sensitive chloride channel 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001034025.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2PDZ0
    Conserved Domains (3) summary
    TIGR00860
    Location:339 → 758
    LIC; Cation transporter family protein
    pfam02931
    Location:338 → 566
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:578 → 755
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  12. NM_001274970.1 → NP_001261899.1  pH-sensitive chloride channel 1, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261899.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCN5
    Conserved Domains (2) summary
    pfam02931
    Location:331 → 534
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:546 → 717
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  13. NM_001274971.1 → NP_001261900.1  pH-sensitive chloride channel 1, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261900.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFD7
    Conserved Domains (3) summary
    TIGR00860
    Location:332 → 750
    LIC; Cation transporter family protein
    pfam02931
    Location:331 → 559
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:571 → 747
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  14. NM_001274968.1 → NP_001261897.1  pH-sensitive chloride channel 1, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261897.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFL8
    Conserved Domains (2) summary
    pfam02931
    Location:331 → 559
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:571 → 742
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  15. NM_001169979.1 → NP_001163450.1  pH-sensitive chloride channel 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163450.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JI08
    Conserved Domains (2) summary
    pfam02931
    Location:338 → 566
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:578 → 666
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  16. NM_001038935.3 → NP_001034024.2  pH-sensitive chloride channel 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001034024.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2PDY9
    Conserved Domains (3) summary
    TIGR00860
    Location:339 → 775
    LIC; Cation transporter family protein
    pfam02931
    Location:338 → 566
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:578 → 772
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  17. NM_001038937.2 → NP_001034026.1  pH-sensitive chloride channel 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001034026.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL69, Q9VUV3
    Conserved Domains (1) summary
    pfam02931
    Location:338 → 524
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A4D6K8E5 A0A4D6K8E5
E1JI08 E1JI08
M9NEB0 M9NEB0
M9NFY2 M9NFY2
M9PCN0 M9PCN0
M9PCN5 M9PCN5
M9PFD4 M9PFD4
M9PFD7 M9PFD7
M9PFL8 M9PFL8
M9PFR7 M9PFR7
M9PI70 M9PI70
Q2PDY9 Q2PDY9
Q2PDZ0 Q2PDZ0
Q5D6V9 Q5D6V9
Q5D6W0 Q5D6W0
Q5D6W1 Q5D6W1
Q95T52 Q95T52
Q9VUV2 Q9VUV2
Q9VUV3 Q9VUV3
X2JCG3 X2JCG3
X2JGQ0 X2JGQ0

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