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GXIVsPLA2 GXIVsPLA2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39734, updated on 9-Dec-2024

Summary

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Official Symbol
GXIVsPLA2provided by FlyBase
Official Full Name
GXIVsPLA2provided by FlyBase
Primary source
FLYBASE:FBgn0036545
Locus tag
Dmel_CG17035
See related
AllianceGenome:FB:FBgn0036545
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17035; Dmel\CG17035; GXIVsPLA
Summary
Predicted to enable calcium ion binding activity and phospholipase A2 activity. Predicted to be involved in arachidonate secretion; lipid catabolic process; and phospholipid metabolic process. Predicted to be located in extracellular region. Is expressed in adult head; foregut anlage in statu nascendi; and organism. Orthologous to human PLA2G12A (phospholipase A2 group XIIA) and PLA2G12B (phospholipase A2 group XIIB). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See GXIVsPLA2 in Genome Data Viewer
Location:
72B2-72B2; 3-43 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15955096..15956465)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15948196..15949565)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene sugar-free frosting Neighboring gene Protein kinase, cAMP-dependent, catalytic subunit 3 Neighboring gene uncharacterized protein Neighboring gene early girl

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila spermatid individualization is sensitive to temperature and fatty acid metabolism. Ben-David G, et al. Spermatogenesis, 2015 Jan-Apr. PMID 26413411, Free PMC Article
  2. PI3K/Akt Cooperates with Oncogenic Notch by Inducing Nitric Oxide-Dependent Inflammation. Villegas SN, et al. Cell Rep, 2018 Mar 6. PMID 29514083
  3. PLA2G12A as a Novel Biomarker for Colorectal Cancer with Prognostic Relevance. Parisi E, et al. Int J Mol Sci, 2023 Jun 30. PMID 37446068, Free PMC Article
  4. Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. Qurashi A, et al. Hum Mol Genet, 2012 May 1. PMID 22298836, Free PMC Article
  5. Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster. Jumbo-Lucioni P, et al. BMC Genomics, 2010 May 11. PMID 20459830, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipase A2 activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arachidonate secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GXIVsPLA2
Names
CG17035-PA
CG17035-PC
CG17035-PD
GXIVsPLA2-PA
GXIVsPLA2-PC
GXIVsPLA2-PD
NP_001137957.1
NP_001261903.1
NP_648815.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15955096..15956465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274974.1 → NP_001261903.1  GXIVsPLA2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261903.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BIV5, Q9VUV6
    Conserved Domains (1) summary
    cl29745
    Location:18 → 199
    Phospholip_A2_3; Prokaryotic phospholipase A2

  2. NM_001144485.3 → NP_001137957.1  GXIVsPLA2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137957.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z059

  3. NM_140558.4 → NP_648815.1  GXIVsPLA2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648815.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BIV5, Q9VUV6
    Related
    FBpp0075264
    Conserved Domains (1) summary
    cl29745
    Location:18 → 199
    Phospholip_A2_3; Prokaryotic phospholipase A2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z059 B7Z059
Q9VUV6 Q9VUV6

Gene LinkOut

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