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Hip14 Huntingtin-interacting protein 14 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39747, updated on 9-Dec-2024

Summary

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Official Symbol
Hip14provided by FlyBase
Official Full Name
Huntingtin-interacting protein 14provided by FlyBase
Primary source
FLYBASE:FBgn0259824
Locus tag
Dmel_CG6017
See related
AllianceGenome:FB:FBgn0259824
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
3L1; CG 6017; CG6017; dHip14; dHIP14; Dmel\CG6017; hip14; HIP14; l(3)72Ad
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in positive regulation of protein secretion; spermatogenesis; and synaptic vesicle exocytosis. Located in Golgi apparatus and synaptic vesicle. Is expressed in several structures, including adult head; brain; central nervous system; embryonic central brain neurons; and larval muscle cell. Orthologous to several human genes including ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Hip14 in Genome Data Viewer
Location:
72C1-72C1; 3-43 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15988236..15992464)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15981336..15985564)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor-like 1 Neighboring gene long non-coding RNA:CR45446 Neighboring gene DNA polymerase delta subunit 1 Neighboring gene herzog Neighboring gene mitochondrial ribosomal protein S31 Neighboring gene mind bomb 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Presynaptic dysfunction in Huntington's disease. Rozas JL, et al. Biochem Soc Trans, 2010 Apr. PMID 20298208
  2. Cysteine string proteins. Gundersen CB. Prog Neurobiol, 2020 May. PMID 32044380
  3. dHIP14-dependent palmitoylation promotes secretion of the BMP antagonist Sog. Kang KH, et al. Dev Biol, 2010 Oct 1. PMID 20599894, Free PMC Article
  4. Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling. Li W, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29180412, Free PMC Article
  5. The S-palmitoylome and DHHC-PAT interactome of Drosophila melanogaster S2R+ cells indicate a high degree of conservation to mammalian palmitoylomes. Porcellato E, et al. PLoS One, 2022. PMID 35960718, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gain of function screen of PATs reveals an essential role of Hip14 in Drosophila host defense.
    Title: Gain of function screen of PATs reveals an essential role of Hip14 in Drosophila host defense.
  2. Our data indicate that Huntingtin-interacting protein 14 (hip14) controls neurotransmitter release by regulating the trafficking of CSP to synapses.
    Title: Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles.
  3. Drosophila Huntingtin-interacting protein 14 (HIP14) is an essential maternal effect gene required for photoreceptor synaptic transmission and for proper in vivo expression of the palmitoylated presynaptic proteins SNAP-25 and cysteine string protein.
    Title: Drosophila huntingtin-interacting protein 14 is a presynaptic protein required for photoreceptor synaptic transmission and expression of the palmitoylated proteins synaptosome-associated protein 25 and cysteine string protein.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Huntingtin-interacting protein 14
Names
CG6017-PA
CG6017-PB
CG6017-PC
Hip14-PA
Hip14-PB
Hip14-PC
ankyrin domain
htt-interacting protein 14
lethal (3) 72Ad
NP_001261910.1
NP_001261911.1
NP_648824.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15988236..15992464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274982.1 → NP_001261911.1  Huntingtin-interacting protein 14, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261911.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VUW9
    Conserved Domains (5) summary
    cd00204
    Location:114 → 233
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01529
    Location:426 → 559
    zf-DHHC; DHHC palmitoyltransferase
    pfam12796
    Location:52 → 142
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:198 → 251
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:77 → 108
    ANK; ANK repeat [structural motif]

  2. NM_140567.3 → NP_648824.1  Huntingtin-interacting protein 14, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648824.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VUW9
    Related
    FBpp0075273
    Conserved Domains (5) summary
    cd00204
    Location:114 → 233
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01529
    Location:426 → 559
    zf-DHHC; DHHC palmitoyltransferase
    pfam12796
    Location:52 → 142
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:198 → 251
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:77 → 108
    ANK; ANK repeat [structural motif]

  3. NM_001274981.1 → NP_001261910.1  Huntingtin-interacting protein 14, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261910.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFE4
    Conserved Domains (5) summary
    cd00204
    Location:114 → 233
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01529
    Location:426 → 559
    zf-DHHC; DHHC palmitoyltransferase
    pfam12796
    Location:52 → 142
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:198 → 251
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:77 → 108
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFE4 M9PFE4
Q9VUW9.1 Q9VUW9

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