Notum notum [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Notumprovided by FlyBase
Official Full Name: notumprovided by FlyBase
Primary source: FLYBASE:FBgn0044028
Locus tag: Dmel_CG13076
See related: AllianceGenome:FB:FBgn0044028
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.482; anon-WO03062410.10; anon-WO03062410.8; CG13076; Dmel\CG13076; l(3)72CDf; l(3)72Da; Not; notum; Nt; ntm; wf; Wf
Summary: Predicted to enable palmitoleyl hydrolase activity. Involved in several processes, including regulation of compound eye pigmentation; regulation of signal transduction; and wing disc dorsal/ventral pattern formation. Located in extracellular space. Is expressed in several structures, including dorsal-ventral compartment boundary of imaginal disc; embryonic precursor of adult hindgut; germ layer; ovarian sheath; and somatic cell of ovariole. Orthologous to human NOTUM (notum, palmitoleoyl-protein carboxylesterase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 72C3-72D1; 3-44 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16023480..16032752)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16016580..16025852)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Notum normally functions to coordinate synaptic structural and functional differentiation via negative regulation of Wg trans-synaptic signaling in the extracellular synaptomatrix.
Title: Notum coordinates synapse development via extracellular regulation of Wingless trans-synaptic signaling.
Notum requires glypicans to suppress Wnt signalling, but does not cleave their glycophosphatidylinositol anchor; structural analyses reveal glycosaminoglycan binding sites on Notum, which probably help Notum to co-localize with Wnt proteins
Title: Notum deacylates Wnt proteins to suppress signalling activity.
Hydrolysis of the Dally-GPI by Notum provides a switch from low to high level signalling by promoting internalisation of the Hh-Patched ligand-receptor complex.
Title: Dally and Notum regulate the switch between low and high level Hedgehog pathway signalling.
notum can cleave mammalian glypticans and GPI-anchored proteins from the cell surface.
Title: Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface.
the long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum
Title: The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum.
Wingful (wf) encodes a potent extracellular feedback inhibitor of Wg. In contrast to the cytoplasmic protein Naked cuticle (Nkd), the only known Wg feedback antagonist, Wf functions during larval stages.
Title: Wingful, an extracellular feedback inhibitor of Wingless.
Identification of a secreted repressor of Wingless activity, which we call Notum.
Title: HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
NOT enables deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables palmitoleyl hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoleyl hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables phospholipase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein depalmitoleylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of compound eye pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	HMP more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wing disc pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed