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LIPE lipase E, hormone sensitive type [ Sus scrofa (pig) ]

Gene ID: 397583, updated on 18-Sep-2024

Summary

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Official Symbol
LIPEprovided by VGNC
Official Full Name
lipase E, hormone sensitive typeprovided by VGNC
Primary source
VGNC:VGNC:98493
See related
Ensembl:ENSSSCG00000003018
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
HSL; REH
Expression
Biased expression in subcutaneous adipose (RPKM 331.9) and longissimus dorsi muscle (RPKM 13.7) See more
Orthologs
human mouse all
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Genomic context

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See LIPE in Genome Data Viewer
Location:
chromosome: 6
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (49543671..49560126)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (45443742..45454621)

Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene distal membrane arm assembly component 2 Neighboring gene CEA cell adhesion molecule 1 Neighboring gene enolase-phosphatase E1 pseudogene Neighboring gene cornifelin Neighboring gene multiple EGF like domains 8 Neighboring gene transmembrane protein 145

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. The porcine hormone-sensitive lipase gene: sequence, structure, polymorphisms and linkage mapping. Harbitz I, et al. Anim Genet, 1999 Feb. PMID 10050278
  2. Differential responses of hormone-sensitive lipase gene to nutritional transition in adipose tissue, liver, and skeletal muscle of pigs. Liu CY, et al. Biochem Mol Biol Int, 1995 Jul. PMID 7549969
  3. FISH on metaphase and interphase chromosomes demonstrates the physical order of the genes for GPI, CRC, and LIPE in pigs. Chowdhary BP, et al. Cytogenet Cell Genet, 1995. PMID 7656591
  4. Chromosomal localization of the hormone sensitive lipase (LIPE) and insulin receptor (INSR) genes in pigs. Gu F, et al. Hereditas, 1992. PMID 1295851
  5. Effect of feed restriction on adipose tissue transcript concentrations in genetically lean and obese pigs. McNeel RL, et al. J Anim Sci, 2000 Apr. PMID 10784183

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables sterol ester esterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables triacylglycerol lipase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in triglyceride catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hormone-sensitive lipase
Names
monoacylglycerol lipase LIPE
retinyl ester hydrolase
NP_999480.2
XP_013844054.2
XP_013844055.1
XP_013844056.1
XP_020949233.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214315.3 → NP_999480.2  hormone-sensitive lipase

    Status: PROVISIONAL

    Source sequence(s)
    AEMK02000041
    UniProtKB/TrEMBL
    A0A8D1PVS2, A0A8D1XXL4
    Conserved Domains (2) summary
    pfam06350
    Location:6 → 314
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:346 → 494
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

    Range
    49543671..49560126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021093574.1 → XP_020949233.1  hormone-sensitive lipase isoform X2

    UniProtKB/TrEMBL
    A0A286ZT25, A0A4X1SKS6, A0A8D1MT16
    Related
    ENSSSCP00000003269.3, ENSSSCT00000003352.4
    Conserved Domains (2) summary
    pfam06350
    Location:52 → 360
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:392 → 540
    Abhydrolase; alpha/beta hydrolases

  2. XM_013988600.2 → XP_013844054.2  hormone-sensitive lipase isoform X1

    UniProtKB/TrEMBL
    A0A4X1SJC7, A0A8D1L7S7
    Conserved Domains (2) summary
    pfam06350
    Location:57 → 365
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:397 → 545
    Abhydrolase; alpha/beta hydrolases

  3. XM_013988602.2 → XP_013844056.1  hormone-sensitive lipase isoform X3

    UniProtKB/TrEMBL
    A0A8D1PVS2, A0A8D1XXL4
    Conserved Domains (2) summary
    pfam06350
    Location:6 → 314
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:346 → 494
    Abhydrolase; alpha/beta hydrolases

  4. XM_013988601.2 → XP_013844055.1  hormone-sensitive lipase isoform X3

    UniProtKB/TrEMBL
    A0A8D1PVS2, A0A8D1XXL4
    Conserved Domains (2) summary
    pfam06350
    Location:6 → 314
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:346 → 494
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68J42.1 GenPept UniProtKB/Swiss-Prot:Q68J42

Gene LinkOut

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