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l(3)72Dn lethal (3) 72Dn [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39774, updated on 9-Dec-2024

Summary

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Official Symbol
l(3)72Dnprovided by FlyBase
Official Full Name
lethal (3) 72Dnprovided by FlyBase
Primary source
FLYBASE:FBgn0263605
Locus tag
Dmel_CG5018
See related
AllianceGenome:FB:FBgn0263605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5018; Dmel\CG5018; l(3)j5A4; UTP4
Summary
Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of small-subunit processome and t-UTP complex. Is expressed in organism. Human ortholog(s) of this gene implicated in cholestasis and primary biliary cholangitis. Orthologous to human UTP4 (UTP4 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See l(3)72Dn in Genome Data Viewer
Location:
72D10-72D10; 3-44 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16226126..16228737, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16219226..16221837, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43891 Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Methionine-CAT 1-3 Neighboring gene Thioredoxin-related transmembrane protein 3 Neighboring gene Programmed Cell Death 5 Neighboring gene Mediator complex subunit 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Scrutinizing the human TEX genes in the context of human male infertility. Sieper MH, et al. Andrology, 2024 Mar. PMID 37594251
  2. Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation. Sanchez CG, et al. Cell Stem Cell, 2016 Feb 4. PMID 26669894, Free PMC Article
  3. Transcriptional response to dietary restriction in Drosophila melanogaster. Ding F, et al. J Insect Physiol, 2014 Oct. PMID 24819200, Free PMC Article
  4. Molecular genetic analyses of polytene chromosome region 72A-D in Drosophila melanogaster reveal a gene desert in 72D. Cooper MT, et al. PLoS One, 2011. PMID 21853143, Free PMC Article
  5. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of t-UTP complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lethal (3) 72Dn
Names
CG5018-PA
CG5018-PB
l(3)72Dn-PA
l(3)72Dn-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16226126..16228737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140589.3 → NP_648846.2  lethal (3) 72Dn, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648846.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T021, Q9VUZ6
    Related
    FBpp0075239
    Conserved Domains (3) summary
    COG2319
    Location:99 → 573
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:74 → 106
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:20 → 268
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001275001.1 → NP_001261930.1  lethal (3) 72Dn, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261930.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFG1, Q8T021
    Conserved Domains (3) summary
    COG2319
    Location:57 → 529
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:74 → 106
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:20 → 268
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFG1 M9PFG1
Q8T021 Q8T021
Q9VUZ6 Q9VUZ6

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