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l(3)72Dr lethal (3) 72Dr [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39778, updated on 4-Jan-2025

Summary

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Official Symbol
l(3)72Drprovided by FlyBase
Official Full Name
lethal (3) 72Drprovided by FlyBase
Primary source
FLYBASE:FBgn0263608
Locus tag
Dmel_CG32154
See related
AllianceGenome:FB:FBgn0263608
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32154; CG5082; Dmel\CG32154
Summary
Predicted to enable gamma-glutamyl-peptidase activity. Predicted to be involved in tetrahydrofolylpolyglutamate metabolic process. Predicted to be active in vacuole. Orthologous to human GGH (gamma-glutamyl hydrolase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See l(3)72Dr in Genome Data Viewer
Location:
72D10-72D10; 3-44 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16237723..16239462)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16230823..16232562)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Mediator complex subunit 10 Neighboring gene lethal (3) 72Dp Neighboring gene Heat shock protein cognate 20 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans. Kislukhin G, et al. G3 (Bethesda), 2013 Aug 7. PMID 23733889, Free PMC Article
  2. Molecular genetic analyses of polytene chromosome region 72A-D in Drosophila melanogaster reveal a gene desert in 72D. Cooper MT, et al. PLoS One, 2011. PMID 21853143, Free PMC Article
  3. Survival Rate and Transcriptional Response upon Infection with the Generalist Parasite Beauveria bassiana in a World-Wide Sample of Drosophila melanogaster. Paparazzo F, et al. PLoS One, 2015. PMID 26154519, Free PMC Article
  4. Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors. Tegeder I, et al. J Neurooncol, 2019 Jan. PMID 30446899
  5. A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins. Guichard A, et al. Cell Rep, 2023 Aug 29. PMID 37480566, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables gamma-glutamyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables omega peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tetrahydrofolylpolyglutamate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lethal (3) 72Dr
Names
CG32154-PA
l(3)72Dr-PA
NP_730120.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16237723..16239462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168656.2 → NP_730120.1  lethal (3) 72Dr [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730120.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VV00
    Related
    FBpp0075215
    Conserved Domains (1) summary
    cd01747
    Location:23 → 313
    GATase1_Glutamyl_Hydrolase; Type 1 glutamine amidotransferase (GATase1) domain found in gamma-Glutamyl Hydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VV00 Q9VV00

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