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ncapd2.S non-SMC condensin I complex subunit D2 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398080, updated on 4-Jan-2025

Summary

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Official Symbol
ncapd2.S
Official Full Name
non-SMC condensin I complex subunit D2 S homeolog
Primary source
Xenbase:XB-GENE-5854852
Locus tag
XELAEV_18036724mg
See related
EnsemblRapid:ENSXLAG00005023197 AllianceGenome:Xenbase:XB-GENE-5854852
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
pEg7; capd2; cnap1; ncapd2
Summary
Predicted to act upstream of or within cell division and mitotic chromosome condensation. Predicted to be located in cytosol. Is expressed in genital system. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NCAPD2 (non-SMC condensin I complex subunit D2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ncapd2.S in Genome Data Viewer
Location:
chromosome: 7S
Exon count:
32
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7S NC_054384.1 (4886803..4914060)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7S NC_030737.1 (4906041..4933251)

Chromosome 7S - NC_054384.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 384 S homeolog Neighboring gene inhibitor of growth family member 4 S homeolog Neighboring gene small nucleolar RNA U85 Neighboring gene small nucleolar RNA U85 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase S homeolog Neighboring gene intermediate filament family orphan 1 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. pEg7, a new Xenopus protein required for mitotic chromosome condensation in egg extracts. Cubizolles F, et al. J Cell Biol, 1998 Dec 14. PMID 9852142, Free PMC Article
  2. 13S condensin actively reconfigures DNA by introducing global positive writhe: implications for chromosome condensation. Kimura K, et al. Cell, 1999 Jul 23. PMID 10428035
  3. Phosphorylation and activation of 13S condensin by Cdc2 in vitro. Kimura K, et al. Science, 1998 Oct 16. PMID 9774278
  4. Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein. Hirano T, et al. Cell, 1997 May 16. PMID 9160743
  5. The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A. Takemoto A, et al. Nat Struct Mol Biol, 2009 Dec. PMID 19915589

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome condensation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic chromosome condensation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
condensin complex subunit 1
Names
13S condensin XCAP-D2 subunit
chromosome assembly protein XCAP-D2
chromosome condensation-related SMC-associated protein 1
chromosome-associated protein D2
eg7
non-SMC condensin I complex, subunit D2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088371.1 → NP_001081840.1  condensin complex subunit 1

    See identical proteins and their annotated locations for NP_001081840.1

    Status: PROVISIONAL

    Source sequence(s)
    AF067969
    UniProtKB/Swiss-Prot
    Q9YGS5, Q9YHY6
    UniProtKB/TrEMBL
    B7ZSB4
    Related
    ENSXLAP00005070796.1, ENSXLAT00005072342.1
    Conserved Domains (5) summary
    COG5098
    Location:57 → 1221
    COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
    pfam12717
    Location:1045 → 1210
    Cnd1; non-SMC mitotic condensation complex subunit 1
    pfam12922
    Location:73 → 236
    Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term
    pfam16000
    Location:1258 → 1354
    CARMIL_C; CARMIL C-terminus
    sd00044
    Location:1031 → 1060
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054384.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    4886803..4914060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041570421.1 → XP_041426355.1  condensin complex subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A1L8FDW9, A0A974H9I9, B7ZSB4
    Conserved Domains (3) summary
    COG5098
    Location:57 → 1216
    COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
    sd00044
    Location:1026 → 1055
    HEAT; HEAT repeat [structural motif]
    pfam16000
    Location:1253 → 1348
    CARMIL_C; CARMIL C-terminus

  2. XM_041570424.1 → XP_041426358.1  condensin complex subunit 1 isoform X2

    UniProtKB/TrEMBL
    A0A8J1L9Z9, B7ZSB4
    Conserved Domains (2) summary
    COG5098
    Location:118 → 1174
    COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
    sd00044
    Location:984 → 1013
    HEAT; HEAT repeat [structural motif]

  3. XM_041570423.1 → XP_041426357.1  condensin complex subunit 1 isoform X2

    UniProtKB/TrEMBL
    A0A8J1L9Z9, B7ZSB4
    Related
    ENSXLAP00005070681.1, ENSXLAT00005072225.1
    Conserved Domains (2) summary
    COG5098
    Location:118 → 1174
    COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
    sd00044
    Location:984 → 1013
    HEAT; HEAT repeat [structural motif]

  4. XM_041570422.1 → XP_041426356.1  condensin complex subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A1L8FDW9, A0A974H9I9, B7ZSB4
    Related
    ENSXLAP00005070230.1, ENSXLAT00005071768.1
    Conserved Domains (3) summary
    COG5098
    Location:57 → 1216
    COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
    sd00044
    Location:1026 → 1055
    HEAT; HEAT repeat [structural motif]
    pfam16000
    Location:1253 → 1348
    CARMIL_C; CARMIL C-terminus

  5. XM_041570425.1 → XP_041426359.1  condensin complex subunit 1 isoform X2

    UniProtKB/TrEMBL
    A0A8J1L9Z9, B7ZSB4
    Conserved Domains (2) summary
    COG5098
    Location:118 → 1174
    COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
    sd00044
    Location:984 → 1013
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9YHY6.1 GenPept UniProtKB/Swiss-Prot:Q9YHY6

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