aos argos [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: aosprovided by FlyBase
Official Full Name: argosprovided by FlyBase
Primary source: FLYBASE:FBgn0004569
Locus tag: Dmel_CG4531
See related: AllianceGenome:FB:FBgn0004569
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Aos; arg; Argos; CG4531; DmAos; Dmel\CG4531; gil; l(3)05845; l(3)05959; l(3)j5E11; l(3)rJ472; l(3)rJ812; l(3)rQ526; rlt; sty
Summary: Enables epidermal growth factor receptor binding activity and receptor antagonist activity. Involved in several processes, including negative regulation of cell differentiation; negative regulation of signal transduction; and regionalization. Located in extracellular space. Is expressed in several structures, including anlage in statu nascendi; epithelium; imaginal disc; midline glial cell; and wing vein. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 73A2-73A2; 3-44 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16470386..16483650, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16463486..16476750, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos.
Title: Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos.
argos is upregulated by Notch in adult muscle progenitors but is repressed in the wing
Title: Context-dependent enhancer selection confers alternate modes of notch regulation on argos.
1.6-A resolution crystal structure of Argos bound to an EGFR ligand
Title: Structural basis for EGFR ligand sequestration by Argos.
Computational analysis was performed on EGFR inhibition by argos.
Title: Computational analysis of EGFR inhibition by Argos.
Argos mutants are deficient in their ability to bind Spitz in vitro
Title: Argos mutants define an affinity threshold for spitz inhibition in vivo.
Argos inhibits EGFR (DER) signalling without interacting directly with the receptor, but instead by sequestering the DER-activating ligand Spitz
Title: Argos inhibits epidermal growth factor receptor signalling by ligand sequestration.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0336 (e-PCR)
- UniSTS:58657

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables epidermal growth factor receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor antagonist activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor antagonist activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in genital disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in haltere development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stem cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oenocyte delamination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ommatidial rotation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed