brca1.L breast cancer 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: brca1.L
Official Full Name: breast cancer 1 L homeolog
Primary source: Xenbase:XB-GENE-6254021
Locus tag: XELAEV_18043845mg
See related: EnsemblRapid:ENSXLAG00005030277 AllianceGenome:Xenbase:XB-GENE-6254021
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: brca1
Summary: Predicted to enable DNA binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Predicted to act upstream of or within several processes, including double-strand break repair via homologous recombination; negative regulation of fatty acid biosynthetic process; and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromosome; nucleus; and plasma membrane. Predicted to be part of BRCA1-A complex and BRCA1-BARD1 complex. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia complementation group S; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human BRCA1 (BRCA1 DNA repair associated). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (34996121..35051771, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (29303118..29358748, complement)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BRCA1 and ELK-1 regulate neural progenitor cell fate in the optic tectum in response to visual experience in Xenopus laevis tadpoles.
Title: BRCA1 and ELK-1 regulate neural progenitor cell fate in the optic tectum in response to visual experience in Xenopus laevis tadpoles.
BRCA1-BARD1 regulates transcription through BRD4 in Xenopus nucleoplasmic extract.
Title: BRCA1-BARD1 regulates transcription through BRD4 in Xenopus nucleoplasmic extract.
MRN (Mre11, Rad50, and Nbs1) complex, CtIP, and BRCA1 are required for both the removal of Top2-DNA adducts and the subsequent resection of Top2-adducted DSB ends.
Title: MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts.
BRCA1-dependent helicase unloading is a critical, early event in DNA interstrand crosslink repair.
Title: BRCA1 promotes unloading of the CMG helicase from a stalled DNA replication fork.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: breast cancer 1 L homeolog

Names: breast and ovarian cancer susceptibility protein; breast cancer 1, early onset

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090779.1 → NP_001084248.1 breast cancer 1 L homeolog

See identical proteins and their annotated locations for NP_001084248.1

Status: PROVISIONAL

Source sequence(s)

AF416868

UniProtKB/TrEMBL

B7ZRE7, Q90X96

Related

ENSXLAP00005091382.1, ENSXLAT00005093061.1

Conserved Domains (4) summary

smart00292
Location:1487 → 1566

BRCT; breast cancer carboxy-terminal domain

cd00162
Location:23 → 69

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00533
Location:1372 → 1447

BRCT; BRCA1 C Terminus (BRCT) domain

pfam12820
Location:348 → 442

BRCT_assoc; Serine-rich domain associated with BRCT

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

34996121..35051771 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)