hid head involution defective [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: hidprovided by FlyBase
Official Full Name: head involution defectiveprovided by FlyBase
Primary source: FLYBASE:FBgn0003997
Locus tag: Dmel_CG5123
See related: AllianceGenome:FB:FBgn0003997
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5123; Dmel\CG5123; Hid; HID; hid1; Hid1; his; l(3)05014; W
Summary: Enables several functions, including BIR domain binding activity; protein sequestering activity; and ubiquitin protein ligase binding activity. Involved in several processes, including autophagic cell death; cellular response to gamma radiation; and instar larval or pupal morphogenesis. Located in mitochondrion; nucleus; and plasma membrane. Is expressed in several structures, including Malpighian tubule; gut section; head epidermis primordium; imaginal disc; and salivary gland. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 75C1-75C1; 3-45 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (18167745..18185641, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (18160845..18178741, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hid is required during pupariation for caspase-dependent pruning of class IV da neurons and Nos and Pum delay pruning.
Title: Nanos-mediated repression of hid protects larval sensory neurons after a global switch in sensitivity to apoptotic signals.
loss of function mutants shows persisting wing epithelial cells and, furthermore, silencing of the hormone bursicon in the CNS produced collective cell death defective phenotypes manifested in the wing epithelium
Title: Hid arbitrates collective cell death in the Drosophila wing.
Shows that in addition to specifying distinct neuronal subtypes over time, temporal patterning of outer proliferation center progenitors also controls the transition in apoptosis by specifying the systematic death of Notch ON neurons in a first phase and of Notch OFF neurons in a second phase through the regulation of Rpr and Hid, respectively.
Title: Temporal patterning of neuroblasts controls Notch-mediated cell survival through regulation of Hid or Reaper.
conclude that dLin52 functions as a co-factor and modulates activity of members of dMyb/dREAM complex at hid promoter, thus regulating apoptosis by repressing this pro-apoptotic gene in the developing Drosophila eye
Title: dLin52 is crucial for dE2F and dRBF mediated transcriptional regulation of pro-apoptotic gene hid.
Study provide evidence that miR-6/11 functions through regulation of the proapoptotic genes, reaper (rpr), head involution defective (hid), grim and sickle (skl).
Title: Overlapping functions of microRNAs in control of apoptosis during Drosophila embryogenesis.
head involution defect protein and transcripts accumulate specifically in polar cells destined to die
Title: Physiological apoptosis of polar cells during Drosophila oogenesis is mediated by Hid-dependent regulation of Diap1.
FoxO targets hid and bim in Drosophila and human, respectively, are responsible for the LRRK2/dLRRK-mediated cell death.
Title: Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila.
Rpr is able to self-associate and also binds to Hid and Grim.
Title: Drosophila IAP antagonists form multimeric complexes to promote cell death.
In the Drosophila eye, Ras may protect cells from apoptosis by inhibiting both JNK and Hid activities.
Title: Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye.
pro-apoptotic gene hid plays an important role in the execution of cell death in Drosophila. (Review)
Title: Regulation of Drosophila melanogaster pro-apoptotic gene hid.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables BIR domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables cysteine-type endopeptidase regulator activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase regulator activity involved in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein sequestering activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antennal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagic cell death	IEP Inferred from Expression Pattern more info	PubMed
involved_in autophagic cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in autophagic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in instar larval or pupal development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut cell programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process involved in development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ecdysone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to red light	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sex differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: head involution defective

Names: CG5123-PA; CG5123-PB; head involuted; head involuted defective; head involution defect; head involution defective 1; head-involution defective; head-involution-defective; hid-PA; hid-PB; wrinkled; wrinkler

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

18167745..18185641 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079412.4 → NP_524136.2 head involution defective, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524136.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24106, Q9VVP1

UniProtKB/TrEMBL

M9PFL5

Related

FBpp0074899

Conserved Domains (1) summary

pfam09770
Location:106 → 226

PAT1; Topoisomerase II-associated protein PAT1
NM_001275081.1 → NP_001262010.1 head involution defective, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262010.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24106, Q9VVP1

UniProtKB/TrEMBL

M9PFL5

Conserved Domains (1) summary

pfam09770
Location:106 → 226

PAT1; Topoisomerase II-associated protein PAT1