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CG5103 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40012, updated on 9-Dec-2024

Summary

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Official Symbol
CG5103provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036784
Locus tag
Dmel_CG5103
See related
AllianceGenome:FB:FBgn0036784
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5103
Summary
Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Predicted to be involved in pentose-phosphate shunt, non-oxidative branch. Predicted to be active in cytosol. Is expressed in adult head and spermatozoon. Orthologous to several human genes including TKT (transketolase) and TKTL2 (transketolase like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG5103 in Genome Data Viewer
Location:
75C3-75C3; 3-45 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18292125..18294262, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18285225..18287362, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45936 Neighboring gene Chemosensory protein A 75a Neighboring gene long non-coding RNA:CR43306 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. grim promotes programmed cell death of Drosophila microchaete glial cells. Wu JN, et al. Mech Dev, 2010 Sep-Dec. PMID 20558283, Free PMC Article
  2. Drosophila sickle is a novel grim-reaper cell death activator. Wing JP, et al. Curr Biol, 2002 Jan 22. PMID 11818064
  3. sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein. Srinivasula SM, et al. Curr Biol, 2002 Jan 22. PMID 11818063, Free PMC Article
  4. Coordinated expression of cell death genes regulates neuroblast apoptosis. Tan Y, et al. Development, 2011 Jun. PMID 21558369, Free PMC Article
  5. Hid arbitrates collective cell death in the Drosophila wing. Garcia-Hughes G, et al. Mech Dev, 2015 Nov. PMID 26226435, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables thiamine pyrophosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transketolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transketolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in pentose-phosphate shunt, non-oxidative branch ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5103-PA
NP_649036.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    18292125..18294262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140779.4 → NP_649036.1  uncharacterized protein Dmel_CG5103 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649036.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MZ62, Q9VVP4
    Related
    FBpp0074898
    Conserved Domains (4) summary
    cd07033
    Location:321 → 474
    TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
    PRK05899
    Location:12 → 621
    PRK05899; transketolase; Reviewed
    cd02012
    Location:19 → 263
    TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...
    pfam02780
    Location:493 → 613
    Transketolase_C; Transketolase, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VVP4 Q9VVP4

Gene LinkOut

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