rpr reaper [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: rprprovided by FlyBase
Official Full Name: reaperprovided by FlyBase
Primary source: FLYBASE:FBgn0011706
Locus tag: Dmel_CG4319
See related: AllianceGenome:FB:FBgn0011706
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0162936.19; CG4319; Dmel\CG4319; Reaper; rp; Rpr; RPR
Summary: Enables several functions, including enzyme binding activity; protein homodimerization activity; and ubiquitin ligase inhibitor activity. Involved in several processes, including autophagic cell death; instar larval or pupal morphogenesis; and regulation of protein metabolic process. Located in mitochondrial outer membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; epithelium; genital disc; gut section; and salivary gland. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 75C6-75C6; 3-45 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (18397535..18398435, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (18390635..18391535, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Shows that in addition to specifying distinct neuronal subtypes over time, temporal patterning of outer proliferation center progenitors also controls the transition in apoptosis by specifying the systematic death of Notch ON neurons in a first phase and of Notch OFF neurons in a second phase through the regulation of Rpr and Hid, respectively.
Title: Temporal patterning of neuroblasts controls Notch-mediated cell survival through regulation of Hid or Reaper.
The rapid induction of apoptosis requires the P53 and is mediated by a stress-responsive regulatory region upstream of reaper. The rapid induction of apoptosis is responsible for preventing the expression of viral genes and blocking the infection.
Title: P53-mediated rapid induction of apoptosis conveys resistance to viral infection in Drosophila melanogaster.
Study provide evidence that miR-6/11 functions through regulation of the proapoptotic genes, reaper (rpr), head involution defective (hid), grim and sickle (skl).
Title: Overlapping functions of microRNAs in control of apoptosis during Drosophila embryogenesis.
dBruce physically interacts with Reaper, dependent upon Reaper's IAP-binding (IBM) and GH3 motifs.
Title: Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER.
Data report here that Drosophila Reaper can induce mitochondrial fragmentation by binding to and inhibiting the pro-fusion protein MFN2 and its Drosophila counterpart dMFN/Marf.
Title: Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death.
findings demonstrate that neuroblast apoptosis during embryogenesis requires the coordinated expression of the cell death genes grim and reaper, and possibly sickle
Title: Coordinated expression of cell death genes regulates neuroblast apoptosis.
Rpr is able to self-associate and also binds to Hid and Grim.
Title: Drosophila IAP antagonists form multimeric complexes to promote cell death.
Eliminating Foxo, together with inhibition of reaper family proapoptotic genes, promotes long-term survival of neuroblasts and sustains neurogenesis in the adult mushroom body, the center for learning and memory.
Title: Inactivation of both Foxo and reaper promotes long-term adult neurogenesis in Drosophila.
The downregulation of alpha-4GT1 during eye development amplifies cell death induction by the pro-apoptotic gene reaper.
Title: Drosophila alpha-1,4-glycosyltransferase (alpha-4GT1) inhibits reaper-mediated apoptosis in the eye.
Data show that all factors studied have very specific temporal and spatial effects on rpr transcription.
Title: Expression of the apoptosis gene reaper in homeotic, segmentation and other mutants in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin conjugating enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin ligase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagic cell death	IEP Inferred from Expression Pattern more info	PubMed
involved_in autophagic cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to ionizing radiation	IDA Inferred from Direct Assay more info	PubMed
involved_in imaginal disc-derived male genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval central nervous system remodeling	TAS Traceable Author Statement more info	PubMed
involved_in larval midgut cell programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ubiquitin-dependent protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ecdysone	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed