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GNBP1 Gram-negative bacteria binding protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40034, updated on 9-Dec-2024

Summary

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Official Symbol
GNBP1provided by FlyBase
Official Full Name
Gram-negative bacteria binding protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0040323
Locus tag
Dmel_CG6895
See related
AllianceGenome:FB:FBgn0040323
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6895; DGNBP-1; DGNBP1; Dmel\CG6895; GNBP; GNBP 1; GNBP-1
Summary
Enables several functions, including (1->3)-beta-D-glucan binding activity; lipopolysaccharide binding activity; and peptidoglycan binding activity. Involved in several processes, including Toll receptor ligand protein activation cascade; defense response to Gram-positive bacterium; and peptidoglycan catabolic process. Located in extracellular space and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See GNBP1 in Genome Data Viewer
Location:
75D6-75D6; 3-45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18675800..18677876)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18668900..18670976)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Caprin Neighboring gene Gram-negative bacteria binding protein 2 Neighboring gene pseudo Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure. Lee SH, et al. Protein Sci, 2006 Feb. PMID 16385003, Free PMC Article
  2. Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA. Wang L, et al. EMBO J, 2006 Oct 18. PMID 17024181, Free PMC Article
  3. Evolution of the βGRP/GNBP/β-1,3-glucanase family of insects. Hughes AL. Immunogenetics, 2012 Jul. PMID 22410636
  4. Wall teichoic acids of Staphylococcus aureus limit recognition by the drosophila peptidoglycan recognition protein-SA to promote pathogenicity. Atilano ML, et al. PLoS Pathog, 2011 Dec. PMID 22144903, Free PMC Article
  5. Clustering of peptidoglycan recognition protein-SA is required for sensing lysine-type peptidoglycan in insects. Park JW, et al. Proc Natl Acad Sci U S A, 2007 Apr 17. PMID 17409189, Free PMC Article

See all (107) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results demonstrate that GNBP1 and PGRP-SA can jointly activate the Toll pathway
    Title: Dual activation of the Drosophila toll pathway by two pattern recognition receptors.
  2. GNBP1 acts upstream of the Toll ligand Spatzle and works in the defense against Gram-positive bacterial infection in Drosophila
    Title: In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults.
  3. GNBP1 presents a processed form of peptidoglycan for sensing by PGRP-SA and that a tripartite interaction between these proteins and peptidoglycan is essential for downstream signaling.
    Title: Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables (1->3)-beta-D-glucan binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables beta-glucanase activity IKR
Inferred from Key Residues
more info
 PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables hydrolase activity IKR
Inferred from Key Residues
more info
 PubMed 
enables lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pattern recognition receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pattern recognition receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables peptidoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Toll receptor ligand protein activation cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Toll receptor ligand protein activation cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in innate immune response-activating signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pattern recognition receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidoglycan catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Gram-negative bacteria binding protein 1
Names
CG6895-PA
GNBP1-PA
glucan-binding protein 1
gram-negative binding protein 1
osiris

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    18675800..18677876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079418.3 → NP_524142.2  Gram-negative bacteria binding protein 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524142.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0ZX67, A0ZX68, A0ZX72
    Related
    FBpp0074817
    Conserved Domains (2) summary
    cd02179
    Location:175 → 491
    GH16_beta_GRP; beta-1,3-glucan recognition protein, member of glycosyl hydrolase family 16
    pfam15886
    Location:21 → 126
    CBM39; Carbohydrate binding domain (family 32)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NHB0.2 Q9NHB0

Gene LinkOut

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