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Dysb Dysbindin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40052, updated on 9-Dec-2024

Summary

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Official Symbol
Dysbprovided by FlyBase
Official Full Name
Dysbindinprovided by FlyBase
Primary source
FLYBASE:FBgn0036819
Locus tag
Dmel_CG6856
See related
AllianceGenome:FB:FBgn0036819
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6856; Ddysb; Dmel\CG6856; dysb; dysbindin; NP_649064
Summary
Involved in several processes, including eye pigment granule organization; learning or memory; and modulation of chemical synaptic transmission. Located in neuromuscular junction of somatic muscle and synaptic vesicle. Part of BLOC-1 complex. Is expressed in adult central brain; adult optic lobe glial cell; embryonic/larval salivary gland; and organism. Used to study metal metabolism disorder and schizophrenia. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome 7 and schizophrenia. Orthologous to human DTNBP1 (dystrobrevin binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Dysb in Genome Data Viewer
Location:
75E2-75E2; 3-45 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18867771..18869219)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18860871..18862319)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45912 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutaredoxin 1 Neighboring gene Rad9 Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DISC1 causes associative memory and neurodevelopmental defects in fruit flies. Furukubo-Tokunaga K, et al. Mol Psychiatry, 2016 Sep. PMID 26976042, Free PMC Article
  2. Visualization of DISC1-Dysbindin interaction in glutamatergic synaptic termini in fruit flies. Furukubo-Tokunaga K, et al. Mol Psychiatry, 2016 Sep. PMID 27545194
  3. The β-alanyl-monoamine synthase ebony is regulated by schizophrenia susceptibility gene dysbindin in Drosophila. Lu B, et al. Sci China Life Sci, 2014 Jan. PMID 24399135
  4. The behavioral and neurochemical characterization of a Drosophila dysbindin mutant supports the contribution of serotonin to schizophrenia negative symptoms. Hidalgo S, et al. Neurochem Int, 2020 Sep. PMID 32416114
  5. The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repression. Baccino-Calace M, et al. Elife, 2022 Jul 7. PMID 35796533, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dysbindin levels regulate the access to EGTA-sensitive vesicles at the neuromuscular junction.
    Title: Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles.
  2. Results indicate that perturbations downstream of DTNBP1, confer susceptibility to copper, a metal that in excess is a neurotoxin and whose depletion constitutes a micronutrient deficiency.
    Title: Neuronal copper homeostasis susceptibility by genetic defects in dysbindin, a schizophrenia susceptibility factor.
  3. Loss-of-function alleles of dysbindin or Blos1 impaired neurotransmitter release and synaptic function and plasticity.
    Title: Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity.
  4. optimal binding ratio between Dysb and Ebony might contribute to such non-linear effects. Thus, Ddysb-dependent regulation of Ebony could be one of the mechanisms that mediate dopamine signal
    Title: The β-alanyl-monoamine synthase ebony is regulated by schizophrenia susceptibility gene dysbindin in Drosophila.
  5. Ddysb regulates glutamatergic transmission through its neuronal function and regulates dopamine metabolism by regulating Ebony expression in glial cells
    Title: Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila.
  6. study found that dysbindin (CG6856) is required presynaptically for the retrograde, homeostatic modulation of neurotransmission, and functions in a dose-dependent manner downstream or independently of calcium influx
    Title: The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eye pigment granule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mating behavior, sex discrimination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of dopamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of dopamine metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in olfactory learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in short-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle recycling via endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of BLOC-1 complex IGI
Inferred from Genetic Interaction
more info
 PubMed 
part_of BLOC-1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in neuromuscular junction of somatic muscle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dysbindin
Names
CG6856-PA
CG6856-PB
Dysb-PA
Dysb-PB
dysbindin ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    18867771..18869219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140807.4 → NP_649064.1  dysbindin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649064.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVT5
    UniProtKB/TrEMBL
    M9PI95
    Related
    FBpp0074829
    Conserved Domains (1) summary
    pfam07851
    Location:94 → 189
    TMPIT; TMPIT-like protein

  2. NM_001275094.1 → NP_001262023.1  dysbindin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262023.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVT5
    UniProtKB/TrEMBL
    M9PI95
    Conserved Domains (1) summary
    pfam07851
    Location:94 → 189
    TMPIT; TMPIT-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PI95 M9PI95
Q9VVT5.1 Q9VVT5

Gene LinkOut

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