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arx asterix [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40061, updated on 9-Dec-2024

Summary

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Official Symbol
arxprovided by FlyBase
Official Full Name
asterixprovided by FlyBase
Primary source
FLYBASE:FBgn0036826
Locus tag
Dmel_CG3893
See related
AllianceGenome:FB:FBgn0036826
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Arx; BcDNA:LD18018; CG3893; Dmel\CG3893; DmGTSF1; gtsf1; Gtsf1
Summary
Enables tRNA binding activity. Involved in negative regulation of DNA-templated transcription; oogenesis; and regulatory ncRNA-mediated gene silencing. Located in nucleus. Is expressed in egg chamber; female germline cell; organism; ovary; and somatic cell of ovariole. Orthologous to human GTSF1 (gametocyte specific factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See arx in Genome Data Viewer
Location:
75E4-75E4; 3-45 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18900595..18901554, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18893695..18894654, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Ribosomal protein L26 Neighboring gene uncharacterized protein Neighboring gene COP9 signalosome subunit 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons. Ipsaro JJ, et al. Cell Rep, 2021 Mar 30. PMID 33789107, Free PMC Article
  2. Crystal structure of Drosophila Piwi. Yamaguchi S, et al. Nat Commun, 2020 Feb 12. PMID 32051406, Free PMC Article
  3. Mechanism and regulation of P element transposition. Ghanim GE, et al. Open Biol, 2020 Dec. PMID 33352068, Free PMC Article
  4. Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing. Murano K, et al. EMBO J, 2019 Sep 2. PMID 31368590, Free PMC Article
  5. Non-Coding RNAs in Transcriptional Regulation: The review for Current Molecular Biology Reports. Chen YA, et al. Curr Mol Biol Rep, 2015 Mar 1. PMID 26120554, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons.
    Title: Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons.
  2. CG3893 is indispensible for transposon silencing but does not affect piRNA levels.
    Title: A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulatory ncRNA-mediated gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transposable element silencing by piRNA-mediated heterochromatin formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
asterix
Names
CG3893-PA
arx-PA
gametocyte-specific factor 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    18900595..18901554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140814.2 → NP_649071.1  asterix [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649071.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SWX0, Q9VVU3
    Related
    FBpp0074842
    Conserved Domains (1) summary
    pfam05253
    Location:4 → 25
    zf-U11-48K; U11-48K-like CHHC zinc finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SWX0.1 Q8SWX0

Gene LinkOut

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