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Acp76A Accessory gland protein 76A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40078, updated on 4-Jan-2025

Summary

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Official Symbol
Acp76Aprovided by FlyBase
Official Full Name
Accessory gland protein 76Aprovided by FlyBase
Primary source
FLYBASE:FBgn0015586
Locus tag
Dmel_CG3801
See related
AllianceGenome:FB:FBgn0015586
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
(Acp)76A; Acp76; CG3801; Dmel\CG3801; Spn76A
Summary
Involved in sexual reproduction. Located in extracellular space. Is expressed in several structures, including adult head; adult hemolymph; female reproductive system; male accessory gland; and male accessory gland main cell. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Acp76A in Genome Data Viewer
Location:
75F5-75F5; 3-45 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19050757..19052026, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19043857..19045126, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing, arthropod-specific, member 2 Neighboring gene naked cuticle Neighboring gene long non-coding RNA:CR45940 Neighboring gene long non-coding RNA:CR44675 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Drosophila male accessory gland protein that is a member of the serpin superfamily of proteinase inhibitors is transferred to females during mating. Coleman S, et al. Insect Biochem Mol Biol, 1995 Feb. PMID 7711750
  2. A role for Acp29AB, a predicted seminal fluid lectin, in female sperm storage in Drosophila melanogaster. Wong A, et al. Genetics, 2008 Oct. PMID 18757944, Free PMC Article
  3. Serpins in arthropod biology. Meekins DA, et al. Semin Cell Dev Biol, 2017 Feb. PMID 27603121, Free PMC Article
  4. Variation in sperm displacement and its association with accessory gland protein loci in Drosophila melanogaster. Clark AG, et al. Genetics, 1995 Jan. PMID 7705622, Free PMC Article
  5. Regulation of the feedback antagonist naked cuticle by Wingless signaling. Chang JL, et al. Dev Biol, 2008 Sep 15. PMID 18585374, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase inhibitor activity IKR
Inferred from Key Residues
more info
 PubMed 
NOT enables serine-type endopeptidase inhibitor activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in sexual reproduction HEP PubMed 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
accessory gland protein 76A
Names
Acp76A-PA
Acp76A-PB
CG3801-PA
CG3801-PB
accessory gland-specific peptide 76A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19050757..19052026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259902.1 → NP_001246831.1  accessory gland protein 76A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246831.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46224, Q9VVW1
    UniProtKB/TrEMBL
    M9NEE3
    Conserved Domains (1) summary
    cl00137
    Location:22 → 366
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  2. NM_079429.2 → NP_524153.1  accessory gland protein 76A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524153.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46224, Q9VVW1
    Related
    FBpp0074805
    Conserved Domains (1) summary
    cl00137
    Location:22 → 367
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NEE3 M9NEE3
Q9VVW1.2 Q9VVW1

Gene LinkOut

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