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brv1 brivido-1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40116, updated on 9-Dec-2024

Summary

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Official Symbol
brv1provided by FlyBase
Official Full Name
brivido-1provided by FlyBase
Primary source
FLYBASE:FBgn0036874
Locus tag
Dmel_CG9472
See related
AllianceGenome:FB:FBgn0036874
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Brivido 1; Brivido1; brv; Brv-1; Brv1; CG9472; CT26822; Dmel\CG9472
Summary
Enables stretch-activated, monoatomic cation-selective, calcium channel activity. Involved in cellular response to cold; detection of mechanical stimulus involved in sensory perception of touch; and detection of temperature stimulus involved in thermoception. Predicted to be active in membrane. Is expressed in antennal lobe glomerulus VP3; aristal sensory neuron VP3; sacculus; and second segment of antenna. Orthologous to human PKD1L3 (polycystin 1 like 3, transient receptor potential channel interacting). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See brv1 in Genome Data Viewer
Location:
76B3-76B3; 3-45 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19483826..19486498, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19476926..19479598, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene hairpin RNA:CR32207 Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene hairpin RNA:CR33940 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Injury-induced cold sensitization in Drosophila larvae involves behavioral shifts that require the TRP channel Brv1. Turner HN, et al. PLoS One, 2018. PMID 30586392, Free PMC Article
  2. Brv1 Is Required for Drosophila Larvae to Sense Gentle Touch. Zhang M, et al. Cell Rep, 2018 Apr 3. PMID 29617663
  3. A gustatory receptor paralogue controls rapid warmth avoidance in Drosophila. Ni L, et al. Nature, 2013 Aug 29. PMID 23925112, Free PMC Article
  4. The coding of temperature in the Drosophila brain. Gallio M, et al. Cell, 2011 Feb 18. PMID 21335241, Free PMC Article
  5. Temperature sensation in Drosophila. Barbagallo B, et al. Curr Opin Neurobiol, 2015 Oct. PMID 25616212, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables stretch-activated, monoatomic cation-selective, calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cellular response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of mechanical stimulus involved in sensory perception of touch IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of temperature stimulus involved in thermoception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
brivido-1
Names
CG9472-PA
brivido
brv1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19483826..19486498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140859.2 → NP_649116.1  brivido-1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649116.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VVZ8
    Related
    FBpp0074750
    Conserved Domains (1) summary
    pfam08016
    Location:165 → 591
    PKD_channel; Polycystin cation channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VVZ8 Q9VVZ8

Gene LinkOut

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