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CG9451 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40118, updated on 9-Dec-2024

Summary

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Official Symbol
CG9451provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036876
Locus tag
Dmel_CG9451
See related
AllianceGenome:FB:FBgn0036876
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG9451
Summary
Predicted to enable acid phosphatase activity. Predicted to be located in extracellular exosome and nucleus. Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1J and prostate cancer. Orthologous to human ACP2 (acid phosphatase 2, lysosomal); ACP3 (acid phosphatase 3); and ACP4 (acid phosphatase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG9451 in Genome Data Viewer
Location:
76B5-76B5; 3-45 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19498197..19500798, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19491297..19493898, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene hairpin RNA:CR33940 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45731

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila FIT is a protein-specific satiety hormone essential for feeding control. Sun J, et al. Nat Commun, 2017 Jan 19. PMID 28102207, Free PMC Article
  2. Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging. Huang J, et al. PNAS Nexus, 2023 Dec. PMID 38059264, Free PMC Article
  3. A behavioral screen for mediators of age-dependent TDP-43 neurodegeneration identifies SF2/SRSF1 among a group of potent suppressors in both neurons and glia. Azpurua J, et al. PLoS Genet, 2021 Nov. PMID 34723963, Free PMC Article
  4. Ectopic expression of S28A-mutated Histone H3 modulates longevity, stress resistance and cardiac function in Drosophila. Joos JP, et al. Sci Rep, 2018 Feb 13. PMID 29440697, Free PMC Article
  5. Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association. Hamilton PT, et al. mBio, 2015 Sep 15. PMID 26374124, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acid phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG9451-PA
CG9451-PB
NP_001262050.1
NP_649118.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19498197..19500798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275121.1 → NP_001262050.1  uncharacterized protein Dmel_CG9451, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262050.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VW00
    Conserved Domains (1) summary
    cd07061
    Location:55 → 355
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

  2. NM_140861.3 → NP_649118.1  uncharacterized protein Dmel_CG9451, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649118.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VW00
    Related
    FBpp0074747
    Conserved Domains (1) summary
    cd07061
    Location:55 → 355
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VW00 Q9VW00

Gene LinkOut

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