Shal Shaker cognate l [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Shalprovided by FlyBase
Official Full Name: Shaker cognate lprovided by FlyBase
Primary source: FLYBASE:FBgn0005564
Locus tag: Dmel_CG9262
See related: AllianceGenome:FB:FBgn0005564
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9262; Dmel\CG9262; DNK[[v]]4; dShal; Kv4; Kv4/Shal; K[[v]]4; Sh-l; shaI; ShaI; shal; Shl
Summary: Enables A-type (transient outward) potassium channel activity. Involved in associative learning and chemical synaptic transmission. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic hindgut; ganglia; larval muscle system; and larval visceral muscle cell. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to several human genes including KCND3 (potassium voltage-gated channel subfamily D member 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 76B7-76B8; 3-45 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19566851..19584568, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19559951..19577668, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identified that Shal/Kv4, a well known voltage-gated K+ channel, acts as a controller of wake-sleep transition at dusk in Drosophila circadian neurons.
Title: Control of Sleep Onset by Shal/K(v)4 Channels in Drosophila Circadian Neurons.
We found that ddaE neurons have an axonal diffusion barrier proximal to the cell body that requires a giant isoform of the neuronal ankyrin Ank2. Furthermore, the potassium channel shal concentrates in the proximal axon in an Ank2-dependent manner
Title: Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment.
The loss of Shal potassium channel induces compensatory rebalancing of ion channel expression.
Title: Krüppel mediates the selective rebalancing of ion channel expression.
In Drosophila, the single Shal/K(v)4 gene encodes the predominant I(A) current in many neuronal cell bodies.
Title: Shal/K(v)4 channels are required for maintaining excitability during repetitive firing and normal locomotion in Drosophila.
Data show that SIDL is expressed primarily in the nervous system, co-localizes with GFP-Shal channels in neurons, and interacts specifically with the LL-motif of Drosophila and mouse Shal channels.
Title: SIDL interacts with the dendritic targeting motif of Shal (K(v)4) K+ channels in Drosophila.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables A-type (transient outward) potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables A-type (transient outward) potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: shaker cognate l

Names: CG9262-PA; CG9262-PB; CG9262-PC; Shaker-like; Shal-PA; Shal-PB; Shal-PC; shaker cognate 1; shaker cognate L

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

19566851..19584568 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001104176.2 → NP_001097646.1 shaker cognate l, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097646.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8JNV8, P17971, Q29R37, Q9VW11

Conserved Domains (3) summary

cd18420
Location:6 → 144

BTB_POZ_Shal-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins

pfam00520
Location:188 → 415

Ion_trans; Ion transport protein

pfam11879
Location:445 → 540

DUF3399; Domain of unknown function (DUF3399)
NM_001275126.1 → NP_001262055.1 shaker cognate l, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262055.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFP1

Conserved Domains (3) summary

cd18420
Location:6 → 144

BTB_POZ_Shal-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins

pfam00520
Location:188 → 415

Ion_trans; Ion transport protein

pfam11879
Location:445 → 490

DUF3399; Domain of unknown function (DUF3399)
NM_079435.4 → NP_524159.1 shaker cognate l, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524159.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P17971

Related

FBpp0074741

Conserved Domains (3) summary

cd18420
Location:6 → 144

BTB_POZ_Shal-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins

pfam00520
Location:188 → 415

Ion_trans; Ion transport protein

pfam11879
Location:445 → 489

DUF3399; Domain of unknown function (DUF3399)