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Rnf146 Ring finger protein 146 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40144, updated on 4-Jan-2025

Summary

Official Symbol
Rnf146provided by FlyBase
Official Full Name
Ring finger protein 146provided by FlyBase
Primary source
FLYBASE:FBgn0036897
Locus tag
Dmel_CG8786
See related
AllianceGenome:FB:FBgn0036897
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GM01527; CG8786; Dmel\CG8786; DRNF146; Iduna; RNF146
Summary
Enables ubiquitin protein ligase activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein destabilization. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human RNF146 (ring finger protein 146). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Rnf146 in Genome Data Viewer
Location:
76B10-76B11; 3-45 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19637207..19642816, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19630307..19635916, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene male sterile (3) 76Cc Neighboring gene wallenda Neighboring gene Ornithine aminotransferase precursor Neighboring gene teyrha-meyrha

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables poly-ADP-D-ribose binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables poly-ADP-D-ribose binding IEA
Inferred from Electronic Annotation
more info
 
enables poly-ADP-D-ribose binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISM
Inferred from Sequence Model
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ring finger protein 146
Names
CG8786-PB
CG8786-PC
CG8786-PF
CG8786-PG
Rnf146-PB
Rnf146-PC
Rnf146-PF
Rnf146-PG
iduna

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19637207..19642816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144507.3NP_001137979.2  ring finger protein 146, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137979.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z077, B7Z078
    Conserved Domains (2) summary
    smart00678
    Location:192264
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd00162
    Location:123165
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. NM_140881.4NP_649138.2  ring finger protein 146, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649138.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZQ1, Q9VW25
    Related
    FBpp0074730
    Conserved Domains (2) summary
    smart00678
    Location:192264
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd00162
    Location:123165
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. NM_001144506.3NP_001137978.1  ring finger protein 146, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137978.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z077, B7Z078
    Conserved Domains (2) summary
    smart00678
    Location:192264
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd00162
    Location:123165
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  4. NM_001144508.3NP_001137980.2  ring finger protein 146, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137980.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z083, D4G7C1
    Conserved Domains (2) summary
    cd00162
    Location:123165
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam02825
    Location:191219
    WWE; WWE domain