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CG42637 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40153, updated on 4-Jan-2025

Summary

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Official Symbol
CG42637provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0261360
Locus tag
Dmel_CG42637
See related
AllianceGenome:FB:FBgn0261360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG42637
Old locus tag
Dmel_CG8742
Summary
Predicted to enable guanylate cyclase activity and signaling receptor activity. Predicted to be involved in cGMP-mediated signaling. Predicted to be located in plasma membrane. Is expressed in adult head. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See CG42637 in Genome Data Viewer
Location:
76C2-76C5; 3-46 cM
Exon count:
20
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19719527..19793569, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19712627..19786669, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene serpentine Neighboring gene Transient receptor potential cation channel, mucolipin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Guanylyl cyclase at 76C Neighboring gene Viral tegument-like deubiquitinase Neighboring gene Sterol regulatory element binding protein Neighboring gene uncharacterized protein Neighboring gene mir-33 stem loop Neighboring gene Ionotropic receptor 76a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila receptor guanylyl cyclase Gyc76C is required for semaphorin-1a-plexin A-mediated axonal repulsion. Ayoob JC, et al. J Neurosci, 2004 Jul 28. PMID 15282266, Free PMC Article
  2. Molecular genetic analysis of Chd3 and polytene chromosome region 76B-D in Drosophila melanogaster. Cooper MT, et al. Genetics, 2010 Jul. PMID 20439780, Free PMC Article
  3. Phylogenetic investigation of Peptide hormone and growth factor receptors in five dipteran genomes. Vogel KJ, et al. Front Endocrinol (Lausanne), 2013. PMID 24379806, Free PMC Article
  4. Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos. Sopko R, et al. Dev Cell, 2014 Oct 13. PMID 25284370, Free PMC Article
  5. In vivo analysis of proteomes and interactomes using Parallel Affinity Capture (iPAC) coupled to mass spectrometry. Rees JS, et al. Mol Cell Proteomics, 2011 Jun. PMID 21447707, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c19776073-19771346 mobile_element_type = transposon:Doc{}1053

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cGMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG42637-PA
CG42637-PB
CG42637-PC
NP_001007096.1
NP_001007097.1
NP_524165.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19719527..19793569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001007096.3 → NP_001007097.1  uncharacterized protein Dmel_CG42637, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001007097.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24051, Q7JQ32
    UniProtKB/TrEMBL
    A4V243
    Conserved Domains (6) summary
    cd06370
    Location:26 → 445
    PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
    smart00044
    Location:860 → 1052
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:543 → 827
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:887 → 1074
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:48 → 412
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:835 → 881
    HNOBA; Heme NO binding associated

  2. NM_001007095.3 → NP_001007096.1  uncharacterized protein Dmel_CG42637, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001007096.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24051, Q7JQ32
    UniProtKB/TrEMBL
    A4V243
    Conserved Domains (6) summary
    cd06370
    Location:26 → 445
    PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
    smart00044
    Location:860 → 1052
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:543 → 827
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:887 → 1074
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:48 → 412
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:835 → 881
    HNOBA; Heme NO binding associated

  3. NM_079441.4 → NP_524165.2  uncharacterized protein Dmel_CG42637, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524165.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24051, Q7JQ32
    UniProtKB/TrEMBL
    A4V243
    Conserved Domains (6) summary
    cd06370
    Location:26 → 445
    PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
    smart00044
    Location:860 → 1052
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:543 → 827
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:887 → 1074
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:48 → 412
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:835 → 881
    HNOBA; Heme NO binding associated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V243 A4V243
Q7JQ32.1

Gene LinkOut

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