U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Deaf1 Deformed epidermal autoregulatory factor-1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40164, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Deaf1provided by FlyBase
Official Full Name
Deformed epidermal autoregulatory factor-1provided by FlyBase
Primary source
FLYBASE:FBgn0013799
Locus tag
Dmel_CG8567
See related
AllianceGenome:FB:FBgn0013799
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8567; Deaf-1; DEAF-1; deaf1; DEAF1; Dmel\CG8567; l(3)76BDv
Summary
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in embryo development; regulation of DNA-templated transcription; and regulation of immune response. Located in nucleus and polytene chromosome. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and larval central nervous system. Human ortholog(s) of this gene implicated in Vulto-van Silfout-de Vries syndrome. Orthologous to human DEAF1 (DEAF1 transcription factor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Deaf1 in Genome Data Viewer
Location:
76D1-76D1; 3-46 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19818174..19830686)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19811274..19823786)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene cycle Neighboring gene fibp Neighboring gene tricornered Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Zinc finger myeloid Nervy DEAF-1 type (ZMYND) domain containing proteins exert molecular interactions to implicate in carcinogenesis. Wu L, et al. Discov Oncol, 2022 Dec 15. PMID 36520265, Free PMC Article
  2. A large-scale RNAi screen identifies Deaf1 as a regulator of innate immune responses in Drosophila. Kuttenkeuler D, et al. J Innate Immun, 2010. PMID 20375635
  3. Regulation by homeoproteins: a comparison of deformed-responsive elements. Pederson JA, et al. Genetics, 2000 Oct. PMID 11014815, Free PMC Article
  4. The tricornered gene, which is required for the integrity of epidermal cell extensions, encodes the Drosophila nuclear DBF2-related kinase. Geng W, et al. Genetics, 2000 Dec. PMID 11102376, Free PMC Article
  5. A sequence motif distinct from Hox binding sites controls the specificity of a Hox response element. Li X, et al. Development, 1999 Dec. PMID 10572035

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in Drosophila.
    Title: A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in Drosophila.
  2. DEAF-1 is a regulator of Drosophila immunity; it activates the expression of Mtk and Drs promoter.
    Title: DEAF-1 regulates immunity gene expression in Drosophila.
  3. effects of loss or gain of DEAF-1 function on Drosophila development
    Title: DEAF-1 function is essential for the early embryonic development of Drosophila.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
deformed epidermal autoregulatory factor-1
Names
CG8567-PA
CG8567-PB
CG8567-PC
CG8567-PD
CG8567-PE
Deaf1-PA
Deaf1-PB
Deaf1-PC
Deaf1-PD
Deaf1-PE
deaf-1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19818174..19830686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275140.1 → NP_001262069.1  deformed epidermal autoregulatory factor-1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262069.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24180
    UniProtKB/TrEMBL
    M9PD02
    Conserved Domains (2) summary
    smart00258
    Location:219 → 291
    SAND; SAND domain
    pfam01753
    Location:521 → 557
    zf-MYND; MYND finger

  2. NM_079445.3 → NP_524169.1  deformed epidermal autoregulatory factor-1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524169.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24180
    UniProtKB/TrEMBL
    M9PD02
    Related
    FBpp0074651
    Conserved Domains (2) summary
    smart00258
    Location:219 → 291
    SAND; SAND domain
    pfam01753
    Location:521 → 557
    zf-MYND; MYND finger

  3. NM_001038944.2 → NP_001034033.1  deformed epidermal autoregulatory factor-1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001034033.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86LC7
    Conserved Domains (2) summary
    smart00258
    Location:219 → 291
    SAND; SAND domain
    pfam01753
    Location:518 → 554
    zf-MYND; MYND finger

  4. NM_001275139.1 → NP_001262068.1  deformed epidermal autoregulatory factor-1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262068.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH34
    Conserved Domains (2) summary
    smart00258
    Location:182 → 254
    SAND; SAND domain
    pfam01753
    Location:484 → 520
    zf-MYND; MYND finger

  5. NM_001275141.1 → NP_001262070.1  deformed epidermal autoregulatory factor-1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262070.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFP9
    Conserved Domains (2) summary
    smart00258
    Location:182 → 254
    SAND; SAND domain
    pfam01753
    Location:481 → 517
    zf-MYND; MYND finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E8NH34 E8NH34
M9PD02 M9PD02
M9PFP9 M9PFP9
Q24180.1 Q24180
Q86LC7 Q86LC7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools