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FRG1 FSHD region gene 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40228, updated on 9-Dec-2024

Summary

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Official Symbol
FRG1provided by FlyBase
Official Full Name
FSHD region gene 1provided by FlyBase
Primary source
FLYBASE:FBgn0036964
Locus tag
Dmel_CG6480
See related
AllianceGenome:FB:FBgn0036964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6480; dFRG1; Dmel\CG6480; DmFRG1
Summary
Predicted to enable actin filament binding activity. Involved in heterochromatin organization. Located in cytoplasm. Used to study facioscapulohumeral muscular dystrophy. Orthologous to human FRG1 (FSHD region gene 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See FRG1 in Genome Data Viewer
Location:
77B1-77B1; 3-47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20295802..20296971, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20288902..20290071, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene golden goal Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43890 Neighboring gene antisense RNA:CR43872 Neighboring gene Peroxin 23 Neighboring gene Squamous cell carcinoma-related oncogene 4 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transgenic Drosophila for Investigating DUX4 and FRG1, Two Genes Associated with Facioscapulohumeral Muscular Dystrophy (FSHD). Jones TI, et al. PLoS One, 2016. PMID 26942723, Free PMC Article
  2. FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis. Neguembor MV, et al. J Mol Cell Biol, 2013 Oct. PMID 23720823
  3. Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants. Guan Z, et al. Learn Mem, 2011. PMID 21422168, Free PMC Article
  4. Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. Somma MP, et al. PLoS Genet, 2008 Jul 18. PMID 18797514, Free PMC Article
  5. Growth deregulation and interaction with host hemocytes contribute to tumor progression in a Drosophila brain tumor model. Voutyraki C, et al. Proc Natl Acad Sci U S A, 2023 Aug 15. PMID 37549261, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in heterochromatin organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in striated muscle dense body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
FSHD region gene 1
Names
CG6480-PA
FRG1-PA
FSHD region gene 1 ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20295802..20296971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140945.3 → NP_649202.1  FSHD region gene 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649202.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q4V3U4, Q9VWA8
    Related
    FBpp0074616
    Conserved Domains (1) summary
    pfam06229
    Location:72 → 260
    FRG1; FRG1-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VWA8.1 Q9VWA8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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