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Spn77Ba Serpin 77Ba [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40234, updated on 9-Dec-2024

Summary

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Official Symbol
Spn77Baprovided by FlyBase
Official Full Name
Serpin 77Baprovided by FlyBase
Primary source
FLYBASE:FBgn0262057
Locus tag
Dmel_CG6680
See related
AllianceGenome:FB:FBgn0262057
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6680; Dmel\CG6680; l(3)77ABi; Q0E8C8_DROME; spn77Ba
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in negative regulation of melanization defense response. Located in extracellular space. Is expressed in adult head; embryonic/larval gut; epithelium; and imaginal disc. Human ortholog(s) of this gene implicated in thrombophilia. Orthologous to human SERPINA10 (serpin family A member 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Spn77Ba in Genome Data Viewer
Location:
77B3-77B4; 3-47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20317190..20320116)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20310290..20313216)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene polo Neighboring gene alpha Soluble NSF attachment protein Neighboring gene antisense RNA:CR43875 Neighboring gene Serpin 77Bb Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Serine protease MP2 activates prophenoloxidase in the melanization immune response of Drosophila melanogaster. An C, et al. PLoS One, 2013. PMID 24260243, Free PMC Article
  2. Spatial regulation of developmental signaling by a serpin. Hashimoto C, et al. Dev Cell, 2003 Dec. PMID 14667416
  3. Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation. Scherfer C, et al. Dev Biol, 2008 Nov 15. PMID 18801354
  4. A serpin that regulates immune melanization in the respiratory system of Drosophila. Tang H, et al. Dev Cell, 2008 Oct. PMID 18854145, Free PMC Article
  5. Expression profiling of Drosophila imaginal discs. Klebes A, et al. Genome Biol, 2002 Jul 24. PMID 12186645, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of melanization defense response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serpin 77Ba
Names
CG6680-PA
CG6680-PB
CG6680-PC
Spn77Ba-PA
Spn77Ba-PB
Spn77Ba-PC
lethal (3) 77ABi

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20317190..20320116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300199.1 → NP_001287128.1  serpin 77Ba, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287128.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E8C8, Q8IGD7, Q95SG7
    Conserved Domains (1) summary
    cd00172
    Location:75 → 444
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  2. NM_140948.4 → NP_649205.3  serpin 77Ba, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649205.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E8C8, Q8IGD7, Q95SG7
    Related
    FBpp0074610
    Conserved Domains (1) summary
    cd00172
    Location:75 → 444
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  3. NM_168844.3 → NP_730512.2  serpin 77Ba, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730512.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E8C8, Q8IGD7, Q95SG7
    Related
    FBpp0074611
    Conserved Domains (1) summary
    cd00172
    Location:75 → 444
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0E8C8.1 Q0E8C8

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